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. 1996 Jan;55(1):25–29. doi: 10.1136/ard.55.1.25

Association of hand and knee osteoarthritis: evidence for a polyarticular disease subset.

R Hirsch 1, M Lethbridge-Cejku 1, W W Scott Jr 1, R Reichle 1, C C Plato 1, J Tobin 1, M C Hochberg 1
PMCID: PMC1010077  PMID: 8572729

Abstract

OBJECTIVE--To examine the association between hand and knee osteoarthritis (OA) in a community based population. METHODS--Radiographs of 695 participants aged > or = 40 years in the Baltimore Longitudinal Study of Aging were read for changes of OA, using Kellgren-Lawrence grade > or = 2 as the case definition. RESULTS--Logistic regression analyses, adjusting for age, gender and body mass index, revealed a significant association between OA in the knee and the following joint groups: distal and proximal interphalangeal (DIP, PIP) and Hand2 (OA in two or more hand joint groups) for grade 2-4 and grade 3-4 disease, and the first carpometacarpal (CMC1) joint for grade 3-4 disease. CONCLUSION--There is an association between OA in hand sites and the knee. The strength of the associations increases with increasing disease severity. For the PIP site, there is a trend toward increasing strength of association for increasing numbers of affected joints and bilateral disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Acheson R. M., Collart A. B. New Haven survey of joint diseases. XVII. Relationship between some systemic characteristics and osteoarthrosis in a general population. Ann Rheum Dis. 1975 Oct;34(5):379–387. doi: 10.1136/ard.34.5.379. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Altman R. D., Fries J. F., Bloch D. A., Carstens J., Cooke T. D., Genant H., Gofton P., Groth H., McShane D. J., Murphy W. A. Radiographic assessment of progression in osteoarthritis. Arthritis Rheum. 1987 Nov;30(11):1214–1225. doi: 10.1002/art.1780301103. [DOI] [PubMed] [Google Scholar]
  3. Bagge E., Bjelle A., Edén S., Svanborg A. Factors associated with radiographic osteoarthritis: results from the population study 70-year-old people in Göteborg. J Rheumatol. 1991 Aug;18(8):1218–1222. [PubMed] [Google Scholar]
  4. Cunningham L. S., Kelsey J. L. Epidemiology of musculoskeletal impairments and associated disability. Am J Public Health. 1984 Jun;74(6):574–579. doi: 10.2105/ajph.74.6.574. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cushnaghan J., Dieppe P. Study of 500 patients with limb joint osteoarthritis. I. Analysis by age, sex, and distribution of symptomatic joint sites. Ann Rheum Dis. 1991 Jan;50(1):8–13. doi: 10.1136/ard.50.1.8. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Dougados M., Gueguen A., Nguyen M., Thiesce A., Listrat V., Jacob L., Nakache J. P., Gabriel K. R., Lequesne M., Amor B. Longitudinal radiologic evaluation of osteoarthritis of the knee. J Rheumatol. 1992 Mar;19(3):378–384. [PubMed] [Google Scholar]
  7. Felson D. T., Naimark A., Anderson J., Kazis L., Castelli W., Meenan R. F. The prevalence of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum. 1987 Aug;30(8):914–918. doi: 10.1002/art.1780300811. [DOI] [PubMed] [Google Scholar]
  8. KELLGREN J. H., LAWRENCE J. S. Osteo-arthrosis and disk degeneration in an urban population. Ann Rheum Dis. 1958 Dec;17(4):388–397. doi: 10.1136/ard.17.4.388. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. KELLGREN J. H., MOORE R. Generalized osteoarthritis and Heberden's nodes. Br Med J. 1952 Jan 26;1(4751):181–187. doi: 10.1136/bmj.1.4751.181. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Kallman D. A., Wigley F. M., Scott W. W., Jr, Hochberg M. C., Tobin J. D. New radiographic grading scales for osteoarthritis of the hand. Reliability for determining prevalence and progression. Arthritis Rheum. 1989 Dec;32(12):1584–1591. doi: 10.1002/anr.1780321213. [DOI] [PubMed] [Google Scholar]
  11. Kallman D. A., Wigley F. M., Scott W. W., Jr, Hochberg M. C., Tobin J. D. New radiographic grading scales for osteoarthritis of the hand. Reliability for determining prevalence and progression. Arthritis Rheum. 1989 Dec;32(12):1584–1591. doi: 10.1002/anr.1780321213. [DOI] [PubMed] [Google Scholar]
  12. Lawrence J. S. Generalized osteoarthrosis in a population sample. Am J Epidemiol. 1969 Nov;90(5):381–389. doi: 10.1093/oxfordjournals.aje.a121083. [DOI] [PubMed] [Google Scholar]
  13. Lethbridge-Cejku M., Tobin J. D., Scott W. W., Jr, Reichle R., Plato C. C., Hochberg M. C. The relationship of age and gender to prevalence and pattern of radiographic changes of osteoarthritis of the knee: data from Caucasian participants in the Baltimore Longitudinal Study of Aging. Aging (Milano) 1994 Oct;6(5):353–357. doi: 10.1007/BF03324264. [DOI] [PubMed] [Google Scholar]
  14. McAlindon T. E., Snow S., Cooper C., Dieppe P. A. Radiographic patterns of osteoarthritis of the knee joint in the community: the importance of the patellofemoral joint. Ann Rheum Dis. 1992 Jul;51(7):844–849. doi: 10.1136/ard.51.7.844. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Schouten J. S., van den Ouweland F. A., Valkenburg H. A. A 12 year follow up study in the general population on prognostic factors of cartilage loss in osteoarthritis of the knee. Ann Rheum Dis. 1992 Aug;51(8):932–937. doi: 10.1136/ard.51.8.932. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Scott W. W., Jr, Lethbridge-Cejku M., Reichle R., Wigley F. M., Tobin J. D., Hochberg M. C. Reliability of grading scales for individual radiographic features of osteoarthritis of the knee. The Baltimore longitudinal study of aging atlas of knee osteoarthritis. Invest Radiol. 1993 Jun;28(6):497–501. [PubMed] [Google Scholar]
  17. Spector T. D., Cooper C. Radiographic assessment of osteoarthritis in population studies: whither Kellgren and Lawrence? Osteoarthritis Cartilage. 1993 Oct;1(4):203–206. doi: 10.1016/s1063-4584(05)80325-5. [DOI] [PubMed] [Google Scholar]
  18. van Saase J. L., van Romunde L. K., Cats A., Vandenbroucke J. P., Valkenburg H. A. Epidemiology of osteoarthritis: Zoetermeer survey. Comparison of radiological osteoarthritis in a Dutch population with that in 10 other populations. Ann Rheum Dis. 1989 Apr;48(4):271–280. doi: 10.1136/ard.48.4.271. [DOI] [PMC free article] [PubMed] [Google Scholar]

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