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. 1996 Jan;55(1):30–33. doi: 10.1136/ard.55.1.30

Analysis of the association between chondrocalcinosis and osteoarthritis: a community based study.

R Sanmarti 1, E Kanterewicz 1, M Pladevall 1, D Pañella 1, J B Tarradellas 1, J M Gomez 1
PMCID: PMC1010078  PMID: 8572730

Abstract

OBJECTIVES--To analyse the association between chondrocalcinosis and osteoarthritis (OA) of the hands and knees in an unselected elderly rural population. METHODS--A community based cross sectional study was performed in individuals randomly selected from a previous epidemiological survey on the prevalence of chondrocalcinosis in people older than 60 years from Osona county, Catalonia, northeastern Spain. Radiological OA (grade 2 or more of Kellgren's classification) was evaluated in 26 individuals with chondrocalcinosis and in 104 controls. A total of 18 articular areas of both knees (medial and lateral tibiofemoral compartments) and hands (first, second and third metacarpophalangeal (MCP), first carpometacarpal, trapezium-scaphoid, radiocarpal and distal radioulnar joints) were studied. RESULTS--Radiological changes of OA in the knees were more common in subjects with chondrocalcinosis than in those without it, with an odds ratio adjusted for age and gender (aOR) of 4.3 (95% confidence interval (CI) 1.6 to 11.8, p = 0.005). OA was also more frequent in almost all areas of the hands in individuals with chondrocalcinosis, though the difference reached statistical significance only in the MCP joints (aOR 3.1; 95% CI 1.1 to 8.8; p = 0.033). However, taking into account the side and the different joint compartments analysed, the association between chondrocalcinosis and OA was significant only in the lateral tibiofemoral compartment and the left MCP joints. CONCLUSIONS--In an elderly population unselected for their rheumatic complaints, there was a real association between OA and chondrocalcinosis. This association was particularly relevant in the lateral tibiofemoral compartment of the knee and in the first three left MCP joints.

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Selected References

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  1. Bensasson M., Dorfmann H., Perez-Busquier M., Solnica J., Mery C., Kahn M. F., de Seze S. Etude radiographique de la main dans 50 cas de chondrocalcinose articulaire primitive. Comparaison avec une série de 100 témoins. Rev Rhum Mal Osteoartic. 1975 Jan;42(1):3–11. [PubMed] [Google Scholar]
  2. Doherty M., Dieppe P., Watt I. Pyrophosphate arthropathy: a prospective study. Br J Rheumatol. 1993 Mar;32(3):189–196. doi: 10.1093/rheumatology/32.3.189. [DOI] [PubMed] [Google Scholar]
  3. Felson D. T., Anderson J. J., Naimark A., Kannel W., Meenan R. F. The prevalence of chondrocalcinosis in the elderly and its association with knee osteoarthritis: the Framingham Study. J Rheumatol. 1989 Sep;16(9):1241–1245. [PubMed] [Google Scholar]
  4. Gordon T. P., Smith M., Ebert B., McCredie M., Brooks P. M. Articular chondrocalcinosis in a hospital population: an Australian experience. Aust N Z J Med. 1984 Oct;14(5):655–659. doi: 10.1111/j.1445-5994.1984.tb05019.x. [DOI] [PubMed] [Google Scholar]
  5. Hansen S. E., Herning M. A comparative study of radiographic changes in knee joints in chondrocalcinosis, osteoarthrosis and rheumatoid arthritis. Scand J Rheumatol. 1984;13(1):85–92. doi: 10.3109/03009748409102672. [DOI] [PubMed] [Google Scholar]
  6. Ledingham J., Regan M., Jones A., Doherty M. Radiographic patterns and associations of osteoarthritis of the knee in patients referred to hospital. Ann Rheum Dis. 1993 Jul;52(7):520–526. doi: 10.1136/ard.52.7.520. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Léonard A., Solnica J., Cauvin M., Houdent G., Mallet E., Brunelle P., Deshayes P. La chondrocalcinose: étude de sa fréquence radiologique et de ses rapports avec l'arthrose. Etude du taux de la parathormone. Rev Rhum Mal Osteoartic. 1977 Oct;44(10):559–564. [PubMed] [Google Scholar]
  8. Martel W., Champion C. K., Thompson G. R., Carter T. L. A roentgenologically distinctive arthropathy in some patients with the pseudogout syndrome. Am J Roentgenol Radium Ther Nucl Med. 1970 Jul;109(3):587–605. doi: 10.2214/ajr.109.3.587. [DOI] [PubMed] [Google Scholar]
  9. Martel W., McCarter D. K., Solsky M. A., Good A. E., Hart W. R., Braunstein E. M., Brady T. M. Further observations on the arthropathy of calcium pyrophosphate crystal deposition disease. Radiology. 1981 Oct;141(1):1–15. doi: 10.1148/radiology.141.1.6270724. [DOI] [PubMed] [Google Scholar]
  10. McCarty D. J. Calcium pyrophosphate dihydrate crystal deposition disease--1975. Arthritis Rheum. 1976 May-Jun;19 (Suppl 3):275–285. doi: 10.1002/1529-0131(197605/06)19:3+<275::aid-art1780190702>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
  11. Resnick D., Niwayama G., Goergen T. G., Utsinger P. D., Shapiro R. F., Haselwood D. H., Wiesner K. B. Clinical, radiographic and pathologic abnormalities in calcium pyrophosphate dihydrate deposition disease (CPPD): pseudogout. Radiology. 1977 Jan;122(1):1–15. doi: 10.1148/122.1.1. [DOI] [PubMed] [Google Scholar]
  12. Resnick D., Utsinger P. D. The wrist arthropathy of "pseudogout" occurring with and without chondrocalcinosis. Radiology. 1974 Dec;113(3):633–641. doi: 10.1148/113.3.633. [DOI] [PubMed] [Google Scholar]
  13. Riestra J. L., Sánchez A., Rodríques-Valverde V., Castillo E., Calderón J. Roentgenographic features of the arthropathy associated with CPPD crystal deposition disease. A comparative study with primary osteoarthritis. J Rheumatol. 1985 Dec;12(6):1154–1158. [PubMed] [Google Scholar]
  14. Sanmartí R., Pañella D., Brancós M. A., Canela J., Collado A., Brugués J. Prevalence of articular chondrocalcinosis in elderly subjects in a rural area of Catalonia. Ann Rheum Dis. 1993 Jun;52(6):418–422. doi: 10.1136/ard.52.6.418. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Sokoloff L., Varma A. A. Chondrocalcinosis in surgically resected joints. Arthritis Rheum. 1988 Jun;31(6):750–756. doi: 10.1002/art.1780310608. [DOI] [PubMed] [Google Scholar]
  16. Thomas R. H., Resnick D., Alazraki N. P., Daniel D., Greenfield R. Compartmental evaluation of osteoarthritis of the knee. A comparative study of available diagnostic modalities. Radiology. 1975 Sep;116(3):585–594. doi: 10.1148/116.3.585. [DOI] [PubMed] [Google Scholar]
  17. Wilkins E., Dieppe P., Maddison P., Evison G. Osteoarthritis and articular chondrocalcinosis in the elderly. Ann Rheum Dis. 1983 Jun;42(3):280–284. doi: 10.1136/ard.42.3.280. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Williams W. V., Cope R., Gaunt W. D., Adelstein E. H., Hoyt T. S., Singh A., Pressly T. A., English R., Schumacher H. R., Jr, Walker S. E. Metacarpophalangeal arthropathy associated with manual labor (Missouri metacarpal syndrome). Clinical radiographic, and pathologic characteristics of an unusual degeneration process. Arthritis Rheum. 1987 Dec;30(12):1362–1371. doi: 10.1002/art.1780301207. [DOI] [PubMed] [Google Scholar]
  19. ZITNAN D., SIT'AJ S. Chondrocalcinosis articularis Section L Clinical and radiological study. Ann Rheum Dis. 1963 May;22:142–152. doi: 10.1136/ard.22.3.142. [DOI] [PMC free article] [PubMed] [Google Scholar]

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