Abstract
OBJECTIVE: To determine the prevalence of autoantibodies to myeloperoxidase (MPO) in a series of patients exposed to silica. METHODS: The study included 52 patients with occupational exposure to silica (mean exposure time seven years) and a control group comprising seven patients with progressive systemic sclerosis (PSS), six patients with systemic lupus erythematosus (SLE), and 15 healthy individuals. Antibodies to MPO were detected using commercial enzyme linked immunosorbent assay (ELISA) plates coated with MPO. Indirect immunoflurescence studies for antineutrophil cytoplasmic antibodies were performed using ethanol and formol fixed neutrophils. Clinical and biological data of individuals exposed to silica were recorded (published previously). RESULTS: Antibodies to MPO were detected in 14 individuals exposed to silica (27%). There was a statistically significant difference in anti-MPO ELISA units between the healthy subjects and patients (SLE, PSS, silica exposed individuals) (p < 0.01), but no difference between the different disease groups. CONCLUSIONS: Individuals chronically exposed to silica, whether or not they have a connective tissue disease, have levels of antibodies to MPO (as detected by ELISA) that are greater than those found in the normal population, but similar to those in patients with systemic diseases not induced by silica (SLE/PSS).
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Chevailler A., Carrere F., Renier G., Hurez D., Subra J. F., Reboul P., Riberi P., Masson C. Silicon nephropathy and myeloperoxidase antibodies. Ann Rheum Dis. 1994 Nov;53(11):781–782. doi: 10.1136/ard.53.11.781-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chevailler A., Carrere F., Renier G., Hurez D., Subra J. F., Reboul P., Riberi P., Masson C. Silicon nephropathy and myeloperoxidase antibodies. Ann Rheum Dis. 1994 Nov;53(11):781–782. doi: 10.1136/ard.53.11.781-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Duerr R. H., Targan S. R., Landers C. J., LaRusso N. F., Lindsay K. L., Wiesner R. H., Shanahan F. Neutrophil cytoplasmic antibodies: a link between primary sclerosing cholangitis and ulcerative colitis. Gastroenterology. 1991 May;100(5 Pt 1):1385–1391. [PubMed] [Google Scholar]
- Falk R. J., Jennette J. C. Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis. N Engl J Med. 1988 Jun 23;318(25):1651–1657. doi: 10.1056/NEJM198806233182504. [DOI] [PubMed] [Google Scholar]
- Nässberger L., Sjöholm A. G., Jonsson H., Sturfelt G., Akesson A. Autoantibodies against neutrophil cytoplasm components in systemic lupus erythematosus and in hydralazine-induced lupus. Clin Exp Immunol. 1990 Sep;81(3):380–383. doi: 10.1111/j.1365-2249.1990.tb05342.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sanchez-Roman J., Wichmann I., Salaberri J., Varela J. M., Nuñez-Roldan A. Multiple clinical and biological autoimmune manifestations in 50 workers after occupational exposure to silica. Ann Rheum Dis. 1993 Jul;52(7):534–538. doi: 10.1136/ard.52.7.534. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Savige J. A., Gallicchio M. C., Stockman A., Cunningham T. J., Rowley M. J., Georgiou T., Davies D. Anti-neutrophil cytoplasm antibodies in rheumatoid arthritis. Clin Exp Immunol. 1991 Oct;86(1):92–98. doi: 10.1111/j.1365-2249.1991.tb05779.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Saxon A., Shanahan F., Landers C., Ganz T., Targan S. A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease. J Allergy Clin Immunol. 1990 Aug;86(2):202–210. doi: 10.1016/s0091-6749(05)80067-3. [DOI] [PubMed] [Google Scholar]