Abstract
2023 marks the 30th anniversary of the discovery of single-domain antibody fragments in camelids, better known as nanobodies. This was the starting point for their tremendous success story in biomedicine. Here we highlight recent advances in the development of nanobodies for the detection of neutralizing SARS-CoV-2 antibodies, as biosensors for monitoring extracellular metabolites and as tracer molecules for non-invasive imaging of immune cells.
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Funding note: Open Access funding enabled and organized by Projekt DEAL.
Footnotes
Arbeitsgruppe Die Brückenprofessur für Pharmazeutische Biotechnologie unter der Leitung von Prof. Dr. Ulrich Rothbauer am NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen dient als Bindeglied für den Wissenstransfer aus der Grundlagenforschung in die anwen dungs orientierte Forschung und Entwicklung. Im Fokus steht die Entwicklung und Funktionalisierung rekombinanter Antikörper (Nano- und Chromobodies) für biomedizinische Anwendungen wie Proteomik, zelluläre und in vivo-Bild-gebung sowie Therapeutika.
Robert Lukowski, Sandra Burgstaller, Desiree Frecot, Teresa Wagner und Ulrich Rothbauer (v. l. n. r.)
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