Skip to main content
NCBI home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1996 May;55(5):317–319. doi: 10.1136/ard.55.5.317

Association of two loci on chromosome 2q with nodal osteoarthritis.

G D Wright 1, A E Hughes 1, M Regan 1, M Doherty 1
PMCID: PMC1010169  PMID: 8660106

Abstract

OBJECTIVE: To search for genetic association between microsatellite marker loci and sibling pairs with nodal osteoarthritis (NOA). METHODS: Using the affected sibling pair method of analysis, genomic DNA from 66 sib pairs with NOA was analysed for association with highly polymorphic microsatellite marker loci. The microsatellite markers were amplified using polymerase chain reaction and typed on polyacrylamide gels. RESULTS: A significant association (p < 0.05) was identified between NOA and two loci on the short arm of chromosome 2 (2q 23-35). Candidate genes for osteoarthritis in this region include: fibronectin, a glycoprotein present in the extracellular matrix of normal cartilage; the alpha 2 chain of collagen type V, a major constituent of bone; and the interleukin-8 receptor, important in the regulation of neutrophil activation and chemotaxis. CONCLUSIONS: The chromosomal region 2q 23-35 requires further detailed study in NOA. Confirmation of these findings in large independent data sets and further analysis of candidate genes in this region will be important in unravelling the molecular basis for this common disease.

Full text

PDF
317

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chevalier X. Fibronectin, cartilage, and osteoarthritis. Semin Arthritis Rheum. 1993 Apr;22(5):307–318. doi: 10.1016/s0049-0172(05)80010-1. [DOI] [PubMed] [Google Scholar]
  2. Ercilla M. G., Brancos M. A., Breysse Y., Alonso G., Vives J., Castillo R., Querol J. R. HLA antigens in Forestier's disease, ankylosing spondylitis, and polyarthrosis of the hands. J Rheumatol Suppl. 1977;3:89–93. [PubMed] [Google Scholar]
  3. Hughes A. E. Optimization of microsatellite analysis for genetic mapping. Genomics. 1993 Feb;15(2):433–434. doi: 10.1006/geno.1993.1083. [DOI] [PubMed] [Google Scholar]
  4. Hull R., Pope F. M. Osteoarthritis and cartilage collagen genes. Lancet. 1989 Jun 10;1(8650):1337–1338. doi: 10.1016/s0140-6736(89)92741-4. [DOI] [PubMed] [Google Scholar]
  5. KELLGREN J. H., MOORE R. Generalized osteoarthritis and Heberden's nodes. Br Med J. 1952 Jan 26;1(4751):181–187. doi: 10.1136/bmj.1.4751.181. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Knowlton R. G., Katzenstein P. L., Moskowitz R. W., Weaver E. J., Malemud C. J., Pathria M. N., Jimenez S. A., Prockop D. J. Genetic linkage of a polymorphism in the type II procollagen gene (COL2A1) to primary osteoarthritis associated with mild chondrodysplasia. N Engl J Med. 1990 Feb 22;322(8):526–530. doi: 10.1056/NEJM199002223220807. [DOI] [PubMed] [Google Scholar]
  7. Lane N. E., Nevitt M. C. Osteoarthritis and bone mass. J Rheumatol. 1994 Aug;21(8):1393–1396. [PubMed] [Google Scholar]
  8. Loughlin J., Irven C., Fergusson C., Sykes B. Sibling pair analysis shows no linkage of generalized osteoarthritis to the loci encoding type II collagen, cartilage link protein or cartilage matrix protein. Br J Rheumatol. 1994 Dec;33(12):1103–1106. doi: 10.1093/rheumatology/33.12.1103. [DOI] [PubMed] [Google Scholar]
  9. Palotie A., Väisänen P., Ott J., Ryhänen L., Elima K., Vikkula M., Cheah K., Vuorio E., Peltonen L. Predisposition to familial osteoarthrosis linked to type II collagen gene. Lancet. 1989 Apr 29;1(8644):924–927. doi: 10.1016/s0140-6736(89)92507-5. [DOI] [PubMed] [Google Scholar]
  10. Pattrick M., Manhire A., Ward A. M., Doherty M. HLA-A, B antigens and alpha 1-antitrypsin phenotypes in nodal generalised osteoarthritis and erosive osteoarthritis. Ann Rheum Dis. 1989 Jun;48(6):470–475. doi: 10.1136/ard.48.6.470. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Radin E. L., Parker H. G., Paul I. L. Pattern of degenerative arthritis. Preferential involvement of distal finger-joints. Lancet. 1971 Feb 20;1(7695):377–379. doi: 10.1016/s0140-6736(71)92213-6. [DOI] [PubMed] [Google Scholar]
  12. Radin E. L., Paul I. L., Rose R. M. Role of mechanical factors in pathogenesis of primary osteoarthritis. Lancet. 1972 Mar 4;1(7749):519–522. doi: 10.1016/s0140-6736(72)90179-1. [DOI] [PubMed] [Google Scholar]
  13. Weeks D. E., Lange K. A multilocus extension of the affected-pedigree-member method of linkage analysis. Am J Hum Genet. 1992 Apr;50(4):859–868. [PMC free article] [PubMed] [Google Scholar]
  14. Weeks D. E., Lange K. The affected-pedigree-member method of linkage analysis. Am J Hum Genet. 1988 Feb;42(2):315–326. [PMC free article] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES