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. 1996 Jun;55(6):399–402. doi: 10.1136/ard.55.6.399

Antiubiquitin antibody in localised and systemic scleroderma.

M Fujimoto 1, S Sato 1, H Ihn 1, K Kikuchi 1, T Tamaki 1, K Tamaki 1, K Takehara 1
PMCID: PMC1010193  PMID: 8694581

Abstract

OBJECTIVE: To determine the presence of antiubiquitin antibody (AUbA) in localised scleroderma and systemic sclerosis, as it is frequently found in the sera of patients with systemic lupus erythematosus (SLE) and has also been shown to have a close relationship with antihistone antibodies that have an important role in scleroderma. METHODS: Serum samples from patients with localised scleroderma (n = 48) and systemic sclerosis (n = 52) were examined by enzyme linked immunosorbent assay. Twenty samples from patients with SLE, 20 from patients with dermatomyositis, and 30 samples from healthy individuals were used as controls. RESULTS: AUbA was demonstrated in 44% of patients with localised scleroderma and in 42% of those with systemic sclerosis. The presence of AUbA correlated with the presence of antihistone antibodies in both localised scleroderma and systemic sclerosis. CONCLUSIONS: AUbA is frequently present in patients with localised scleroderma and systemic sclerosis. Induction of AUbA is closely associated with that of antihistone antibodies, suggesting that ubiquitinated histone may be the target in autoimmune responses of these disorders.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bohan A., Peter J. B. Polymyositis and dermatomyositis (first of two parts). N Engl J Med. 1975 Feb 13;292(7):344–347. doi: 10.1056/NEJM197502132920706. [DOI] [PubMed] [Google Scholar]
  2. Davie J. R., Nickel B. E. The ubiquitinated histone species are enriched in histone H1-depleted chromatin regions. Biochim Biophys Acta. 1987 Aug 25;909(3):183–189. doi: 10.1016/0167-4781(87)90076-5. [DOI] [PubMed] [Google Scholar]
  3. Fujimoto M., Sato S., Ihn H., Kikuchi K., Tamaki K., Takehara K. Autoantibodies to pyruvate dehydrogenase complex in patients with systemic sclerosis. Possible role of anti-E1 alpha antibody as a serologic indicator for development of primary biliary cirrhosis. Arthritis Rheum. 1995 Jul;38(7):985–989. doi: 10.1002/art.1780380715. [DOI] [PubMed] [Google Scholar]
  4. Fujimoto M., Sato S., Ihn H., Takehara K. Autoantibodies to the heat-shock protein hsp73 in localized scleroderma. Arch Dermatol Res. 1995;287(6):581–585. doi: 10.1007/BF00374080. [DOI] [PubMed] [Google Scholar]
  5. LeRoy E. C., Black C., Fleischmajer R., Jablonska S., Krieg T., Medsger T. A., Jr, Rowell N., Wollheim F. Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol. 1988 Feb;15(2):202–205. [PubMed] [Google Scholar]
  6. Manetto V., Perry G., Tabaton M., Mulvihill P., Fried V. A., Smith H. T., Gambetti P., Autilio-Gambetti L. Ubiquitin is associated with abnormal cytoplasmic filaments characteristic of neurodegenerative diseases. Proc Natl Acad Sci U S A. 1988 Jun;85(12):4501–4505. doi: 10.1073/pnas.85.12.4501. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Muller S., Briand J. P., Van Regenmortel M. H. Presence of antibodies to ubiquitin during the autoimmune response associated with systemic lupus erythematosus. Proc Natl Acad Sci U S A. 1988 Nov;85(21):8176–8180. doi: 10.1073/pnas.85.21.8176. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Plaué S., Muller S., van Regenmortel M. H. A branched, synthetic octapeptide of ubiquitinated histone H2A as target of autoantibodies. J Exp Med. 1989 May 1;169(5):1607–1617. doi: 10.1084/jem.169.5.1607. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Sato S., Ihn H., Kikuchi K., Takehara K. Antihistone antibodies in systemic sclerosis. Association with pulmonary fibrosis. Arthritis Rheum. 1994 Mar;37(3):391–394. doi: 10.1002/art.1780370313. [DOI] [PubMed] [Google Scholar]
  10. Sato S., Ihn H., Soma Y., Igarashi A., Tamaki T., Kikuchi K., Ishibashi Y., Takehara K. Antihistone antibodies in patients with localized scleroderma. Arthritis Rheum. 1993 Aug;36(8):1137–1141. doi: 10.1002/art.1780360815. [DOI] [PubMed] [Google Scholar]
  11. Schultz D. R., Arnold P. I. Heat shock (stress) proteins and autoimmunity in rheumatic diseases. Semin Arthritis Rheum. 1993 Jun;22(6):357–374. doi: 10.1016/s0049-0172(05)80028-9. [DOI] [PubMed] [Google Scholar]
  12. Steen V. D., Powell D. L., Medsger T. A., Jr Clinical correlations and prognosis based on serum autoantibodies in patients with systemic sclerosis. Arthritis Rheum. 1988 Feb;31(2):196–203. doi: 10.1002/art.1780310207. [DOI] [PubMed] [Google Scholar]
  13. Tan E. M., Cohen A. S., Fries J. F., Masi A. T., McShane D. J., Rothfield N. F., Schaller J. G., Talal N., Winchester R. J. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982 Nov;25(11):1271–1277. doi: 10.1002/art.1780251101. [DOI] [PubMed] [Google Scholar]
  14. Winfield J. B., Jarjour W. N. Stress proteins, autoimmunity, and autoimmune disease. Curr Top Microbiol Immunol. 1991;167:161–189. doi: 10.1007/978-3-642-75875-1_10. [DOI] [PubMed] [Google Scholar]
  15. Young D., Lathigra R., Hendrix R., Sweetser D., Young R. A. Stress proteins are immune targets in leprosy and tuberculosis. Proc Natl Acad Sci U S A. 1988 Jun;85(12):4267–4270. doi: 10.1073/pnas.85.12.4267. [DOI] [PMC free article] [PubMed] [Google Scholar]

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