Skip to main content
NCBI home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1996 Sep;55(9):642–644. doi: 10.1136/ard.55.9.642

Value of synovial fluid interleukin-1 beta determination in predicting the outcome of psoriatic monoarthritis.

L Punzi 1, N Bertazzolo 1, M Pianon 1, E Rizzi 1, P Rossini 1, P Gambari 1
PMCID: PMC1010262  PMID: 8882136

Abstract

OBJECTIVE: To investigate the value of synovial fluid analysis in predicting the outcome of psoriatic monoarthritis. METHODS: In synovial fluid from knee joints of 18 patients with psoriatic monoarthritis lasting less than six months, white blood cell count, acid phosphatase, lysozyme, and interleukin (IL)-1 beta were determined. ESR and serum C reactive protein were also measured. To define the outcome, the patients were monitored for at least three years and then subdivided into those with polyarthritis and those without. RESULTS: Among the blood and synovial fluid indices considered, synovial fluid IL-1 beta was the only variable which differed between the patients who developed polyarthritis, within three years and those without polyarthritis after this time, at 20.82(SD 8.79) v 4.19(4.73) pg ml-1, P < 0.0001). A correlation was found between synovial fluid IL-1 beta concentrations and the number of affected joints after three years (r = 0.739, P < 0.0001). CONCLUSIONS: Determination of synovial fluid IL-1 beta at disease onset may be useful in revealing the outcome of psoriatic monoarthritis since, among the variables considered in our study, this was the only one capable of predicting the evolution of monoarticular psoriatic arthritis to polyarthritis.

Full text

PDF
642

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cork M. J., Tarlow J. K., Blakemore A. I., Mee J. B., Crane A. M., Stierle C., Bleehen S. S., Duff G. W. Psoriasis and interleukin-1. A translation. J R Coll Physicians Lond. 1993 Oct;27(4):366–366. [PMC free article] [PubMed] [Google Scholar]
  2. Danis V. A., Kulesz A. J., Nelson D. S., Brooks P. M. The effect of gold sodium thiomalate and auranofin on lipopolysaccharide-induced interleukin-1 production by blood monocytes in vitro: variation in healthy subjects and patients with arthritis. Clin Exp Immunol. 1990 Mar;79(3):335–340. doi: 10.1111/j.1365-2249.1990.tb08092.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Dayer J. M., Fenner H. The role of cytokines and their inhibitors in arthritis. Baillieres Clin Rheumatol. 1992 Jun;6(2):485–516. doi: 10.1016/s0950-3579(05)80186-4. [DOI] [PubMed] [Google Scholar]
  4. Gladman D. D., Farewell V. T. The role of HLA antigens as indicators of disease progression in psoriatic arthritis. Multivariate relative risk model. Arthritis Rheum. 1995 Jun;38(6):845–850. doi: 10.1002/art.1780380619. [DOI] [PubMed] [Google Scholar]
  5. Jones S. M., Armas J. B., Cohen M. G., Lovell C. R., Evison G., McHugh N. J. Psoriatic arthritis: outcome of disease subsets and relationship of joint disease to nail and skin disease. Br J Rheumatol. 1994 Sep;33(9):834–839. doi: 10.1093/rheumatology/33.9.834. [DOI] [PubMed] [Google Scholar]
  6. Luukkainen R., Kaarela K., Huhtala H., Auerma K., Merilahti-Palo R. Prognostic significance of synovial fluid analysis in rheumatoid arthritis. Ann Med. 1989 Aug;21(4):269–271. doi: 10.3109/07853898909149204. [DOI] [PubMed] [Google Scholar]
  7. Miossec P., Elhamiani M., Chichehian B., D'Angeac A. D., Sany J., Hirn M. Interleukin 2 (IL 2) inhibitor in rheumatoid synovial fluid: correlation with prognosis and soluble IL 2 receptor levels. J Clin Immunol. 1990 Mar;10(2):115–120. doi: 10.1007/BF00918193. [DOI] [PubMed] [Google Scholar]
  8. Moll J. M., Wright V. Psoriatic arthritis. Semin Arthritis Rheum. 1973;3(1):55–78. doi: 10.1016/0049-0172(73)90035-8. [DOI] [PubMed] [Google Scholar]
  10. Punzi L., Ramonda R., Glorioso S., Schiavon F., Mariuz S., Gambari P. F. Predictive value of synovial fluid analysis in juvenile chronic arthritis. Ann Rheum Dis. 1992 Apr;51(4):522–524. doi: 10.1136/ard.51.4.522. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Santamaria P., Gehrz R. C., Bryan M. K., Barbosa J. J. Involvement of class II MHC molecules in the LPS-induction of IL-1/TNF secretions by human monocytes. Quantitative differences at the polymorphic level. J Immunol. 1989 Aug 1;143(3):913–922. [PubMed] [Google Scholar]
  12. di Giovine F. S., Takhsh E., Blakemore A. I., Duff G. W. Single base polymorphism at -511 in the human interleukin-1 beta gene (IL1 beta). Hum Mol Genet. 1992 Sep;1(6):450–450. doi: 10.1093/hmg/1.6.450. [DOI] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES