Skip to main content
PMC home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1996 Sep;55(9):671–673. doi: 10.1136/ard.55.9.671

Obstetric and gynaecological factors in susceptibility to peripheral joint osteoarthritis.

A J Silman 1, J Newman 1
PMCID: PMC1010274  PMID: 8882147

Abstract

There is clear evidence that the age period coinciding with the peak age of the menopause is associated with an increased prevalence of osteoarthritis and this fits in with clinical observation of high likelihood of presentation at this age. A number of pieces of biological evidence also support the notion that changes in sex hormone status might influence risk of degenerative disease at peripheral joint sites. There do not appear, however, to be any important epidemiological predictors based on menstrual or obstetric history that might be useful in predicting who these women might be.

Full text

PDF
671

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson J. J., Felson D. T. Factors associated with osteoarthritis of the knee in the first national Health and Nutrition Examination Survey (HANES I). Evidence for an association with overweight, race, and physical demands of work. Am J Epidemiol. 1988 Jul;128(1):179–189. doi: 10.1093/oxfordjournals.aje.a114939. [DOI] [PubMed] [Google Scholar]
  2. Da Silva J. A., Larbre J. P., Seed M. P., Cutolo M., Villaggio B., Scott D. L., Willoughby D. A. Sex differences in inflammation induced cartilage damage in rodents. The influence of sex steroids. J Rheumatol. 1994 Feb;21(2):330–337. [PubMed] [Google Scholar]
  3. Hannan M. T., Felson D. T., Anderson J. J., Naimark A., Kannel W. B. Estrogen use and radiographic osteoarthritis of the knee in women. The Framingham Osteoarthritis Study. Arthritis Rheum. 1990 Apr;33(4):525–532. doi: 10.1002/art.1780330410. [DOI] [PubMed] [Google Scholar]
  4. Rosner I. A., Goldberg V. M., Getzy L., Moskowitz R. W. Effects of estrogen on cartilage and experimentally induced osteoarthritis. Arthritis Rheum. 1979 Jan;22(1):52–58. doi: 10.1002/art.1780220108. [DOI] [PubMed] [Google Scholar]
  5. Rosner I. A., Goldberg V. M., Moskowitz R. W. Estrogens and osteoarthritis. Clin Orthop Relat Res. 1986 Dec;(213):77–83. [PubMed] [Google Scholar]
  6. Rosner I. A., Malemud C. J., Goldberg V. M., Papay R. S., Getzy L., Moskowitz R. W. Pathologic and metabolic responses of experimental osteoarthritis to estradiol and an estradiol antagonist. Clin Orthop Relat Res. 1982 Nov-Dec;(171):280–286. [PubMed] [Google Scholar]
  7. Samanta A., Jones A., Regan M., Wilson S., Doherty M. Is osteoarthritis in women affected by hormonal changes or smoking? Br J Rheumatol. 1993 May;32(5):366–370. doi: 10.1093/rheumatology/32.5.366. [DOI] [PubMed] [Google Scholar]
  8. Schouten J. S., van den Ouweland F. A., Valkenburg H. A. Natural menopause, oophorectomy, hysterectomy and the risk of osteoarthritis of the dip joints. Scand J Rheumatol. 1992;21(4):196–200. doi: 10.3109/03009749209099221. [DOI] [PubMed] [Google Scholar]
  9. Sheridan P. J., Aufdemorte T. B., Holt G. R., Gates G. A. Cartilage of the baboon contains estrogen receptors. Rheumatol Int. 1985;5(6):279–281. doi: 10.1007/BF00541356. [DOI] [PubMed] [Google Scholar]
  10. Spector T. D., Brown G. C., Silman A. J. Increased rates of previous hysterectomy and gynaecological operations in women with osteoarthritis. BMJ. 1988 Oct 8;297(6653):899–900. doi: 10.1136/bmj.297.6653.899. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Spector T. D., Hart D. J., Brown P., Almeyda J., Dacre J. E., Doyle D. V., Silman A. J. Frequency of osteoarthritis in hysterectomized women. J Rheumatol. 1991 Dec;18(12):1877–1883. [PubMed] [Google Scholar]
  12. Spector T. D., Roman E., Silman A. J. The pill, parity, and rheumatoid arthritis. Arthritis Rheum. 1990 Jun;33(6):782–789. doi: 10.1002/art.1780330604. [DOI] [PubMed] [Google Scholar]
  13. Tepper S., Hochberg M. C. Factors associated with hip osteoarthritis: data from the First National Health and Nutrition Examination Survey (NHANES-I). Am J Epidemiol. 1993 May 15;137(10):1081–1088. doi: 10.1093/oxfordjournals.aje.a116611. [DOI] [PubMed] [Google Scholar]
  14. Tsai C. L., Liu T. K. Estradiol-induced knee osteoarthrosis in ovariectomized rabbits. Clin Orthop Relat Res. 1993 Jun;(291):295–302. [PubMed] [Google Scholar]
  15. Young P. C., Stack M. T. Estrogen and glucocorticoid receptors in adult canine articular cartilage. Arthritis Rheum. 1982 May;25(5):568–573. doi: 10.1002/art.1780250512. [DOI] [PubMed] [Google Scholar]
  16. van Saase J. L., van Romunde L. K., Cats A., Vandenbroucke J. P., Valkenburg H. A. Epidemiology of osteoarthritis: Zoetermeer survey. Comparison of radiological osteoarthritis in a Dutch population with that in 10 other populations. Ann Rheum Dis. 1989 Apr;48(4):271–280. doi: 10.1136/ard.48.4.271. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES