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Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1996 Nov;55(11):841–843. doi: 10.1136/ard.55.11.841

Thrombin receptor expression in rheumatoid and osteoarthritic synovial tissue.

R Morris 1, P G Winyard 1, L F Brass 1, D R Blake 1, C J Morris 1
PMCID: PMC1010322  PMID: 8976643

Abstract

OBJECTIVE: To investigate the possibility that synovial cells might respond to thrombin in the inflamed human joint, using immunohistochemical detection of thrombin receptors. METHODS: Frozen sections of synovial membrane from 20 patients with rheumatoid arthritis, 16 with osteoarthritis, and four normal controls were stained using a monoclonal antibody to the human thrombin receptor. Sections were also double stained for both receptors and non-specific esterase. RESULTS: Receptor positive cells were present in rheumatoid synovia, with some cells also staining positively for non-specific esterase. In contrast, both osteoarthritic and normal synovia contained very few cells expressing receptors. CONCLUSIONS: Thrombin may mediate important pathological changes during chronic inflammatory joint disease.

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Selected References

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