Skip to main content
PMC home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1996 Nov;55(11):852–855. doi: 10.1136/ard.55.11.852

Serum soluble interleukin-2 receptor levels in familial Mediterranean fever.

E Erken 1, R Güneşaçar 1, S Ozbek 1, K Konca 1
PMCID: PMC1010325  PMID: 8976646

Abstract

OBJECTIVE: To investigate serum soluble interleukin-2 receptor (sIL-2R) in familial Mediterranean fever (FMF) and assess its role in acute FMF crisis. METHODS: Serum sIL-2R concentrations were measured in patients with FMF during acute crises and during inactive periods of the disease, using an immunoenzymatic assay kit. Twenty four FMF patients during acute crisis (active FMF), 17 patients with inactive FMF, 24 healthy controls, and 20 active patients with rheumatoid arthritis (as a disease control group) were studied. RESULTS: Serum sIL-2R concentrations were increased during an acute FMF crisis compared with the values in inactive FMF patients and healthy controls (P = 0.0105 and P = 0.0012 respectively), while there was no significant difference between the mean values in active FMF and rheumatoid arthritis patients (P = 0.7325). In 14 of the FMF group whose blood samples were available in both active and inactive phases, sIL-2R concentrations were significantly higher in an acute attack than in an attack-free period (P = 0.027). CONCLUSIONS: An increase in sIL-2R may be a result of hyperreactivity of IL-2R-expressing cells during an acute inflammatory attack of FMF.

Full text

PDF
852

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Campen D. H., Horwitz D. A., Quismorio F. P., Jr, Ehresmann G. R., Martin W. J. Serum levels of interleukin-2 receptor and activity of rheumatic diseases characterized by immune system activation. Arthritis Rheum. 1988 Nov;31(11):1358–1364. doi: 10.1002/art.1780311103. [DOI] [PubMed] [Google Scholar]
  2. Ilfeld D., Weil S., Kuperman O. Immunoregulatory abnormalities in familial Mediterranean fever. Clin Immunol Immunopathol. 1981 Feb;18(2):261–267. doi: 10.1016/0090-1229(81)90032-5. [DOI] [PubMed] [Google Scholar]
  3. Keystone E. C., Snow K. M., Bombardier C., Chang C. H., Nelson D. L., Rubin L. A. Elevated soluble interleukin-2 receptor levels in the sera and synovial fluids of patients with rheumatoid arthritis. Arthritis Rheum. 1988 Jul;31(7):844–849. doi: 10.1002/art.1780310704. [DOI] [PubMed] [Google Scholar]
  4. Knecht A., de Beer F. C., Pras M. Serum amyloid A protein in familial Mediterranean fever. Ann Intern Med. 1985 Jan;102(1):71–72. doi: 10.7326/0003-4819-102-1-71. [DOI] [PubMed] [Google Scholar]
  5. LANSBURY J., HAUT D. D. Quantitation of the manifestations of rheumatoid arthritis. 4. Area of joint surfaces as an index to total joint inflammation and deformity. Am J Med Sci. 1956 Aug;232(2):150–155. [PubMed] [Google Scholar]
  6. Matsumoto T., Iwasaki K. Clinical and laboratory parameters which affect soluble interleukin-2 receptor levels in the serum and synovial fluids of patients with rheumatoid arthritis. Ann Rheum Dis. 1993 Dec;52(12):876–880. doi: 10.1136/ard.52.12.876. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Matzner Y., Brzezinski A. C5a-inhibitor deficiency in peritoneal fluids from patients with familial Mediterranean fever. N Engl J Med. 1984 Aug 2;311(5):287–290. doi: 10.1056/NEJM198408023110503. [DOI] [PubMed] [Google Scholar]
  8. Matzner Y., Partridge R. E., Levy M., Babior B. M. Diminished activity of a chemotactic inhibitor in synovial fluids from patients with familial Mediterranean fever. Blood. 1984 Mar;63(3):629–633. [PubMed] [Google Scholar]
  9. Melamed A., Cabili S., Zakuth V., Spirer Z. The immune regulation in familial Mediterranean fever (FMF). J Clin Lab Immunol. 1988 Jul;26(3):125–128. [PubMed] [Google Scholar]
  10. Rozenbaum M., Katz R., Rozner I., Pollack S. Decreased interleukin 1 activity released from circulating monocytes of patients with familial Mediterranean fever during in vitro stimulation by lipopolysaccharide. J Rheumatol. 1992 Mar;19(3):416–418. [PubMed] [Google Scholar]
  11. Schattner A., Lachmi M., Livneh A., Pras M., Hahn T. Tumor necrosis factor in familial Mediterranean fever. Am J Med. 1991 Apr;90(4):434–438. [PubMed] [Google Scholar]
  12. Wolf R. E., Brelsford W. G. Soluble interleukin-2 receptors in systemic lupus erythematosus. Arthritis Rheum. 1988 Jun;31(6):729–735. doi: 10.1002/art.1780310605. [DOI] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES