Table 2:
Reverse MR analysis. The table shows the results of MR analysis with the subcortical brain structures as exposure and the biomarkers that were significant in the primary analysis as the outcomes. Table 2A shows the results for proteins and 2B shows the results for the metabolites. N SNPs is the number of genetic instruments used for the analysis.
| Region (Exposure) | Biomarker ID (Outcome) | N SNPs | Beta | SE | p-value |
|---|---|---|---|---|---|
| (2A) Proteins | |||||
|
| |||||
| Accumbens | SCGB1C1.5960.49.3 | 7 | 5.84E-05 | 0.00143 | 0.967 |
| Accumbens | SERPING1.4479.14.2 | 7 | 0.0024 | 0.00175 | 0.159 |
| Amygdala | GZMA.3440.7.2 | 17 | 0.0001 | 0.00048 | 0.795 |
| Caudate | TMPRSS11D.6547.83.3 | 24 | 0.00018 | 0.00021 | 0.377 |
| Caudate | TXNDC12.4815.25.3 | 24 | −0.00026 | 0.00023 | 0.268 |
| Hippocampus | C5orf38.6378.2.3 | 18 | −0.00066 | 0.00025 | 0.008 |
| Hippocampus | CPNE1.5346.24.3 | 18 | −0.00126 | 0.00119 | 0.288 |
| Hippocampus | CTF1.13732.79.3 | 18 | −0.00022 | 0.00025 | 0.369 |
| Hippocampus | VIMP.11286.78.3 | 18 | −0.00019 | 0.00025 | 0.435 |
| Putamen | ASIP.5676.54.3 | 28 | −0.00014 | 0.00017 | 0.410 |
| Thalamus | CTRB1.5671.1.3 | 28 | 0.00005 | 0.00015 | 0.743 |
|
| |||||
| (2B) Metabolites | |||||
|
| |||||
| Amygdala | Uridine | 6 | −3E-06 | 7.28E-05 | 0.967 |
| Amygdala | Arachidonate | 6 | 7.84E-05 | 0.0001 | 0.437 |
| Caudate | Mannose | 8 | −8.23E-05 | 4.21E-05 | 0.051 |
| Thalamus | Urate | 12 | −7.89E-06 | 1.69E-05 | 0.641 |
| Thalamus | 1-arachidonoylglycerphosphocholine | 12 | −4.13E-05 | 3.73E-05 | 0.267 |
| Thalamus | N-acetylornithine | 12 | −3.60E-05 | 5.05E-05 | 0.475 |