Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis (Adv. Sci. 11/2023)

Abstract

Immune Engineering

In article number 2202720, Nunzio Bottini, Nisarg J. Shah, and co‐workers report the development of microparticles as a new potential therapy for autoimmune arthritis. When injected in inflamed joints, the microparticles slowly biodegrade and release an immunomodulatory agent that strengthens disease‐protective immune cells. In mouse models of disease, the treatment approach protects joints from damage systemically while avoiding generalized immunosuppression.