In the “Abstracts” published in Mov Disord Clin Pract. 2022;9(S1):S8–S73, the first abstract was missing. The abstract is below. We apologize for this error.
Dentato‐rubro‐thalamic tract as a potential target for Deep Brain Stimulation in Cerebellar Ataxia.
Armas‐Salazar A. Jesús Q. Beltran. Ladrón de Guevara M. Castillo‐Ortega A. Villegas‐López FA. Navarro‐Olvera JL. Carrillo‐Ruiz JD.
Stereotactic & Functional Neurosurgery Service, General Hospital of Mexico, Mexico City.
Objective: Cerebellar ataxia is a condition that represents difficulties in management due to the unsatisfactory results of emergent therapies (Transcranial magnetic stimulation) [1], for this reason, we consider it convenient to explore new therapeutic alternatives through the use of deep brain stimulation (DBS).
Background: Teixeira et al. (2015) performed the only procedure reported for the control of ataxia by using DBS in a patient with history of ischemic injury of the right cerebellar hemisphere, using the dentate nucleus as a therapeutic objective, observing an improvement (32%) in the scale for the assessment and rating of ataxia [2, 3]. As there is not enough evidence, we decided to use a computer simulation to assimilate cerebellar physiology to make a target proposal, as an alternative to the use of animal models [4, 5].
Methods: It was intended to replicate the characteristics of a software made by R.C. Miall, et al. 1993 [6], which resembles the motor control of the cerebellum to a Smith predictor model, in order to correlate this model to the cerebellar physio‐anatomy by analyzing its behavior in different circumstances that represent an uncontrolled model (cerebellar ataxia), and through manipulation of the model variables evaluate which sites allow control to be returned to the system (movement control), determining possible therapeutic targets for DBS.
Results: Preliminary results allow to observe that a delay in cerebellar inputs [Fig. 1A], conditions oscillations in the system (movement disorder). A noteworthy aspect about the relationship between Smith's predictive model and cerebellar physio‐anatomy [Fig. 1B], is the dentato‐rubro‐thalamic‐tract. (DRTt) due to the fact that by manipulating variables in the internal loop of Smith's predicted model (250 ms delay), a compensation is observed in the system that allows restoring the operation of the control model [Fig. 1 C].
Conclusions: DBS in the dentate nucleus (DRTt) ideally in a closed loop system that allows mediating the afferents and efferences in time, could be an effective alternative for the management of ataxia.
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