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Doxorubicin cellular toxicity study of 27 induced by the click reaction with tetrazine 20 in HeLa Cells. The cells were incubated for three days with the indicated compounds at 37 °C after which cellular viability was assessed using a CCK‐8 assay. EC50 curves and values for 3,6‐dimethyl‐1,2,4,5‐tetrazine (Tz (20), in purple), TCO‐doxorubicin (TCO‐DOX (27), in green), TCO‐doxorubicin with 10 equiv. of tetrazine 20 (TCO‐DOX (27)+Tz (20), in red) and doxorubicin (DOX, in blue).
