Skip to main content
PMC home page
The Western Journal of Medicine logoLink to The Western Journal of Medicine
. 1983 Jul;139(1):36–40.

Treatment of Advanced Malignancy With Plasma Perfused Over Staphylococcal Protein A

F Roy MacKintosh, Kim Bennett, Steven Schiff, John Shields, Stephen W Hall
PMCID: PMC1010873  PMID: 6624080

Abstract

A total of 14 extensively pretreated patients with advanced and progressive malignancy were given 140 infusions of autologous plasma that had been perfused over staphylococcal protein A bound to an agarose gel (Sepharose). Infusions ranged in volume from 35 ml to 260 ml (mean, 70 ml), and the quantity of protein A used ranged from 1 to 30 mg per 100 ml of plasma (mean, 10 mg). Acute toxic reactions included fever (21%), chills (18%), nausea (17%), vomiting (8%), pain (9%) and bronchospasm (2%). Four patients did not have an acute toxic reaction and no chronic or cumulative toxic effects were identified. In two patients there was objective tumor regression and in five there was stabilization of disease lasting from 4 to 12 weeks. Further study of this treatment modality is warranted.

Full text

PDF

Images in this article

39Image
on p.39

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baldwin R. W., Price M. R., Robins R. A. Blocking of lymphocyte-mediated cytotoxicity for rat hepatoma cells by tumour-specific antigen-antibody complexes. Nat New Biol. 1972 Aug 9;238(84):185–186. doi: 10.1038/newbio238185a0. [DOI] [PubMed] [Google Scholar]
  2. Bansal S. C., Bansal B. R., Boland J. P. Blocking and unblocking serum factors in neoplasia. Curr Top Microbiol Immunol. 1976;75:45–76. doi: 10.1007/978-3-642-66530-1_2. [DOI] [PubMed] [Google Scholar]
  3. Bansal S. C., Bansal B. R., Thomas H. L., Siegel P. D., Rhoads J. E., Jr, Cooper D. R., Terman D. S., Mark R. Ex vivo removal of serum IgG in a patient with colon carcinoma: some biochemical, immunological and histological observations. Cancer. 1978 Jul;42(1):1–18. doi: 10.1002/1097-0142(197807)42:1<1::aid-cncr2820420102>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
  4. Hellström K. E., Hellström I. Does perfusion with treated plasma cure cancer? N Engl J Med. 1981 Nov 12;305(20):1215–1216. doi: 10.1056/NEJM198111123052011. [DOI] [PubMed] [Google Scholar]
  5. Hellström K. E., Hellström I. Lymphocyte-mediated cytotoxicity and blocking serum activity to tumor antigens. Adv Immunol. 1974;18:209–277. doi: 10.1016/s0065-2776(08)60311-9. [DOI] [PubMed] [Google Scholar]
  6. Holohan T. V., Phillips T. M., Bowles C., Deisseroth A. Regression of canine mammary carcinoma after immunoadsorption therapy. Cancer Res. 1982 Sep;42(9):3663–3668. [PubMed] [Google Scholar]
  7. Israel L., Edelstein R., Mannoni P., Radot E., Greenspan E. M. Plasmapheresis in patients with disseminated cancer: clinical results and correlation with changes in serum protein. The concept of "nonspecific blocking factors". Cancer. 1977 Dec;40(6):3146–3154. doi: 10.1002/1097-0142(197712)40:6<3146::aid-cncr2820400659>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
  8. Jones F. R., Yoshida L. H., Ladiges W. C., Kenny M. A. Treatment of feline leukemia and reversal of FeLV by ex vivo removal of IgG: a preliminary report. Cancer. 1980 Aug 15;46(4):675–684. doi: 10.1002/1097-0142(19800815)46:4<675::aid-cncr2820460408>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
  9. Ray P. K., Idiculla A., Mark R., Rhoads J. E., Jr, Thomas H., Bassett J. G., Cooper D. R. Extracorporeal immunoadsorption of plasma from a metastatic colon carcinoma patient by protein A-containing nonviable Staphylococcus aureus: clinical, biochemical, serologic, and histologic evaluation of the patient's response. Cancer. 1982 May 1;49(9):1800–1809. doi: 10.1002/1097-0142(19820501)49:9<1800::aid-cncr2820490912>3.0.co;2-6. [DOI] [PubMed] [Google Scholar]
  10. Tamerius J., Nepom J., Hellström I., Hellström K. E. Tumor-associated blocking factors: isolation from sera of tumor-bearing mice. J Immunol. 1976 Mar;116(3):724–730. [PubMed] [Google Scholar]
  11. Terman D. S. Tumoricidal responses in spontaneous canine neoplasms after extracorporeal perfusion over immobilized protein A. Fed Proc. 1981 Jan;40(1):45–49. [PubMed] [Google Scholar]
  12. Terman D. S., Yamamoto T., Mattioli M., Cook G., Tillquist R., Henry J., Poser R., Daskal Y. Extensive necrosis of spontaneous canine mammary adenocarcinoma after extracorporeal perfusion over Staphylococcus aureus Cowans I. I. Description of acute tumoricidal response: morphologic, histologic, immunohistochemical, immunologic, and serologic findings. J Immunol. 1980 Feb;124(2):795–805. [PubMed] [Google Scholar]
  13. Terman D. S., Young J. B., Shearer W. T., Ayus C., Lehane D., Mattioli C., Espada R., Howell J. F., Yamamoto T., Zaleski H. I. Preliminary observations of the effects on breast adenocarcinoma of plasma perfused over immobilized protein A. N Engl J Med. 1981 Nov 12;305(20):1195–1200. doi: 10.1056/NEJM198111123052006. [DOI] [PubMed] [Google Scholar]

Articles from Western Journal of Medicine are provided here courtesy of BMJ Publishing Group

RESOURCES