Abstract
Most major chronic diseases probably result from environmental factors accumulating over time in genetically susceptible persons. A detailed family history assessment can help identify the subset of the general population with a strong predisposition to certain major diseases. An understanding of the environmental factors promoting disease development will facilitate more effective prevention or delay disease in a targeted susceptible population. To effectively use this growing knowledge in genetics and epidemiology, health professionals need to motivate people to follow sound recommendations for preventing and delaying disease.
To increase the efficiency and effectiveness of strategies for health promotion and disease prevention, family history data can help determine those diseases for which persons have the greatest risk. They can then concentrate their primary efforts on those preventive measures that will most likely benefit them.
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Selected References
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- Botstein D., White R. L., Skolnick M., Davis R. W. Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet. 1980 May;32(3):314–331. [PMC free article] [PubMed] [Google Scholar]
- Brinton L. A., Williams R. R., Hoover R. N., Stegens N. L., Feinleib M., Fraumeni J. F., Jr Breast cancer risk factors among screening program participants. J Natl Cancer Inst. 1979 Jan;62(1):37–44. [PubMed] [Google Scholar]
- Edwards C. Q., Carroll M., Bray P., Cartwright G. E. Hereditary hemochromatosis. Diagnosis in siblings and children. N Engl J Med. 1977 Jul 7;297(1):7–13. doi: 10.1056/NEJM197707072970102. [DOI] [PubMed] [Google Scholar]
- Hopkins P. N., Williams R. R. A survey of 246 suggested coronary risk factors. Atherosclerosis. 1981 Aug-Sep;40(1):1–52. doi: 10.1016/0021-9150(81)90122-2. [DOI] [PubMed] [Google Scholar]
- Hopkins P. N., Williams R. R., Hunt S. C. Magnified risks from cigarette smoking for coronary prone families in Utah. West J Med. 1984 Aug;141(2):196–202. [PMC free article] [PubMed] [Google Scholar]
- Hunt S. C., Williams R. R., Skolnick M. H., Lyon J. L., Smart C. R. Breast cancer and reproductive history from genealogical data. J Natl Cancer Inst. 1980 May;64(5):1047–1053. [PubMed] [Google Scholar]
- MacMahon B., Cole P., Brown J. Etiology of human breast cancer: a review. J Natl Cancer Inst. 1973 Jan;50(1):21–42. doi: 10.1093/jnci/50.1.21. [DOI] [PubMed] [Google Scholar]
- Marmot M. G., Syme S. L., Kagan A., Kato H., Cohen J. B., Belsky J. Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California: prevalence of coronary and hypertensive heart disease and associated risk factors. Am J Epidemiol. 1975 Dec;102(6):514–525. doi: 10.1093/oxfordjournals.aje.a112189. [DOI] [PubMed] [Google Scholar]
- Miettinen M. Prevention of coronary heart disease by cholesterol lowering diet. Postgrad Med J. 1975;51(8):47–51. [PubMed] [Google Scholar]
- Williams R. R., Feinleib M., Connor R. J., Stegens N. L. Case-control study of antihypertensive and diuretic use by women with malignant and benign breast lesions detected in a mammography screening program. J Natl Cancer Inst. 1978 Aug;61(2):327–335. [PubMed] [Google Scholar]
- Williams R. R., Horm J. W. Association of cancer sites with tobacco and alcohol consumption and socioeconomic status of patients: interview study from the Third National Cancer Survey. J Natl Cancer Inst. 1977 Mar;58(3):525–547. doi: 10.1093/jnci/58.3.525. [DOI] [PubMed] [Google Scholar]
- Williams R. R., Skolnick M., Carmelli D., Maness A. T., Hunt S. C., Hasstedt S., Reiber G. E., Jones R. K. Utah pedigree studies: design and preliminary data for premature male CHD deaths. Prog Clin Biol Res. 1979;32:711–729. [PubMed] [Google Scholar]
- Winawer S. J. Screening for colorectal cancer: an overview. Cancer. 1980 Mar 15;45(5 Suppl):1093–1098. doi: 10.1002/1097-0142(19800315)45:5+<1093::aid-cncr2820451311>3.0.co;2-d. [DOI] [PubMed] [Google Scholar]