Fig. 1.

The embryonic origin of dermal fibroblasts across anatomical sites. (A) Murine dermal fibroblasts in various anatomical locations are derived from different embryonic cell types. (B) The emergence of dorsal dermal fibroblasts from the dermomyotome expressing engrailed 1 (En1) transcription factor (green) under the control of surface ectoderm Wnts. Streams of dermal fibroblasts precursors emerge from the dermomyotome and migrate under the surface ectoderm towards the neural tube and laterally in dorsum.