Use of different types of PROM in oncology trials with different indications. PROMs are classified into three major categories, generic quality of life (QoL) measures (olive), measures for symptom, function or safety (cyan) and indication-specific measures (purple). (A) The measure counts (y axis) are plotted versus the number of pivotal trials corresponding to indications mentioned on the x axis. Generic QoL measures are further divided into EQ-5D, EORTC QLQ-C30, FACT-G and other generic QoL measures; Indication-specific measures are divided into EORTC QLQ modular, FACT modular and other indication-specific measures. (B) The numbers in the Venn diagram indicate the number of included pivotal trials, using the Venn diagram to represent the use of multiple different types of PROMs in a single trial. Abbreviations: EQ-5D, EuroQol Five Dimensions Questionnaire; EORTC QLQ, European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire; FACT, the Functional Assessment of Cancer Therapy; EORTC QLQ-C30, EORTC QLQ-core questionnaire; FACT-G, FACT- General.