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. 1985 Aug;61(4):279–282. doi: 10.1136/sti.61.4.279

Psychosocial impact of chronic infection with hepatitis B virus on British patients.

A S Lok, D J van Leeuwen, H C Thomas, S Sherlock
PMCID: PMC1011831  PMID: 4018808

Abstract

The effects of chronic infection with hepatitis B virus (HBV) on the lives of 40 British patients were studied by means of a questionnaire. The aspects considered were: social, sexual, and family life, physical and psychological health, and work. Thirty six patients considered their lives to have been affected, nine mildly, 14 moderately, and 13 severely. The aspects of life most affected were: sexual (13), psychological (11), physical (5), work (3), social (2), and family (2). Most of the problems encountered were related to infectivity. The availability of vaccines against HBV and of successful antiviral treatment have solved some of the problems, but it remains important for the medical profession to be aware of the multifaceted impact of the carriage of HBV.

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Selected References

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  1. Adler M. W., Belsey E. M., McCutchan J. A., Mindel A. Should homosexuals be vaccinated against hepatitis B virus? Cost and benefit assessment. Br Med J (Clin Res Ed) 1983 May 21;286(6378):1621–1624. doi: 10.1136/bmj.286.6378.1621. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Alter H. J., Purcell R. H., Gerin J. L., London W. T., Kaplan P. M., McAuliffe V. J., Wagner J., Holland P. V. Transmission of hepatitis B to chimpanzees by hepatitis B surface antigen-positive saliva and semen. Infect Immun. 1977 Jun;16(3):928–933. doi: 10.1128/iai.16.3.928-933.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bancroft W. H., Snitbhan R., Scott R. M., Tingpalapong M., Watson W. T., Tanticharoenyos P., Karwacki J. J., Srimarut S. Transmission of hepatitis B virus to gibbons by exposure to human saliva containing hepatitis B surface antigen. J Infect Dis. 1977 Jan;135(1):79–85. doi: 10.1093/infdis/135.1.79. [DOI] [PubMed] [Google Scholar]
  4. Bassendine M. F., Chadwick R. G., Salmeron J., Shipton U., Thomas H. C., Sherlock S. Adenine arabinoside therapy in HBsAg-positive chronic liver disease: a controlled study. Gastroenterology. 1981 May;80(5 Pt 1):1016–1022. [PubMed] [Google Scholar]
  5. Beasley R. P., Hwang L. Y., Lin C. C., Chien C. S. Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan. Lancet. 1981 Nov 21;2(8256):1129–1133. doi: 10.1016/s0140-6736(81)90585-7. [DOI] [PubMed] [Google Scholar]
  6. Bernier R. H., Sampliner R., Gerety R., Tabor E., Hamilton F., Nathanson N. Hepatitis B infection in households of chronic carriers of hepatitis B surface antigen: factors associated with prevalence of infection. Am J Epidemiol. 1982 Aug;116(2):199–211. doi: 10.1093/oxfordjournals.aje.a113406. [DOI] [PubMed] [Google Scholar]
  7. Berninger M., Hammer M., Hoyer B., Gerin J. L. An assay for the detection of the DNA genome of hepatitis B virus in serum. J Med Virol. 1982;9(1):57–68. doi: 10.1002/jmv.1890090109. [DOI] [PubMed] [Google Scholar]
  8. Crosnier J., Jungers P., Couroucé A. M., Laplanche A., Benhamou E., Degos F., Lacour B., Prunet P., Cerisier Y., Guesry P. Randomised placebo-controlled trial of hepatitis B surface antigen vaccine in French haemodialysis units: I, Medical staff. Lancet. 1981 Feb 28;1(8218):455–459. doi: 10.1016/s0140-6736(81)91847-x. [DOI] [PubMed] [Google Scholar]
  9. Crosnier J., Jungers P., Couroucé A. M., Laplanche A., Benhamou E., Degos F., Lacour B., Prunet P., Cerisier Y., Guesry P. Randomised placebo-controlled trial of hepatitis B surface antigen vaccine in french haemodialysis units: II, Haemodialysis patients. Lancet. 1981 Apr 11;1(8224):797–800. doi: 10.1016/s0140-6736(81)92679-9. [DOI] [PubMed] [Google Scholar]
  10. Dietzman D. E., Harnisch J. P., Ray C. G., Alexander E. R., Holmes K. K. Hepatitis B surface antigen (HBsAg) and antibody to HBsAg. Prevalence in homosexual and heterosexual men. JAMA. 1977 Dec 12;238(24):2625–2626. [PubMed] [Google Scholar]
  11. Dudley F. J., Scheuer P. J., Sherlock S. Natural history of hepatitis-associated antigen-positive chronic liver disease. Lancet. 1972 Dec 30;2(7792):1388–1393. doi: 10.1016/s0140-6736(72)92963-7. [DOI] [PubMed] [Google Scholar]
  12. Feinman S. V., Krassnitski O., Sinclair J. C., Wrobel D. M., Berris B. Hepatitis B surface antigen in saliva of HB-SAg carriers. J Lab Clin Med. 1975 Jun;85(6):1042–1048. [PubMed] [Google Scholar]
  13. Francis D. P., Hadler S. C., Thompson S. E., Maynard J. E., Ostrow D. G., Altman N., Braff E. H., O'Malley P., Hawkins D., Judson F. N. The prevention of hepatitis B with vaccine. Report of the centers for disease control multi-center efficacy trial among homosexual men. Ann Intern Med. 1982 Sep;97(3):362–366. doi: 10.7326/0003-4819-97-3-362. [DOI] [PubMed] [Google Scholar]
  14. Heathcote J., Cameron C. H., Dane D. S. Hepatitis-B antigen in saliva and semen. Lancet. 1974 Jan 19;1(7847):71–73. doi: 10.1016/s0140-6736(74)92289-2. [DOI] [PubMed] [Google Scholar]
  15. Lok A. S., Weller I. V., Karayiannis P., Brown D., Fowler M. J., Monjardino J., Thomas H. C., Sherlock S. Thrice weekly lymphoblastoid interferon is effective in inhibiting hepatitis B virus replication. Liver. 1984 Feb;4(1):45–49. doi: 10.1111/j.1600-0676.1984.tb00906.x. [DOI] [PubMed] [Google Scholar]
  16. Mulley A. G., Silverstein M. D., Dienstag J. L. Indications for use of hepatitis B vaccine, based on cost-effectiveness analysis. N Engl J Med. 1982 Sep 9;307(11):644–652. doi: 10.1056/NEJM198209093071103. [DOI] [PubMed] [Google Scholar]
  17. Schreeder M. T., Thompson S. E., Hadler S. C., Berquist K. R., Zaidi A., Maynard J. E., Ostrow D., Judson F. N., Braff E. H., Nylund T. Hepatitis B in homosexual men: prevalence of infection and factors related to transmission. J Infect Dis. 1982 Jul;146(1):7–15. doi: 10.1093/infdis/146.1.7. [DOI] [PubMed] [Google Scholar]
  18. Scott R. M., Snitbhan R., Bancroft W. H., Alter H. J., Tingpalapong M. Experimental transmission of hepatitis B virus by semen and saliva. J Infect Dis. 1980 Jul;142(1):67–71. doi: 10.1093/infdis/142.1.67. [DOI] [PubMed] [Google Scholar]
  19. Scullard G. H., Andres L. L., Greenberg H. B., Smith J. L., Sawhney V. K., Neal E. A., Mahal A. S., Popper H., Merigan T. C., Robinson W. S. Antiviral treatment of chronic hepatitis B virus infection: improvement in liver disease with interferon and adenine arabinoside. Hepatology. 1981 May-Jun;1(3):228–232. doi: 10.1002/hep.1840010306. [DOI] [PubMed] [Google Scholar]
  20. Scullard G. H., Pollard R. B., Smith J. L., Sacks S. L., Gregory P. B., Robinson W. S., Merigan T. C. Antiviral treatment of chronic hepatitis B virus infection. I. Changes in viral markers with interferon combined with adenine arabinoside. J Infect Dis. 1981 Jun;143(6):772–783. doi: 10.1093/infdis/143.6.772. [DOI] [PubMed] [Google Scholar]
  21. Szmuness W., Much I., Prince A. M., Hoofnagle J. H., Cherubin C. E., Harley E. J., Block G. H. On the role of sexual behavior in the spread of hepatitis B infection. Ann Intern Med. 1975 Oct;83(4):489–495. doi: 10.7326/0003-4819-83-4-489. [DOI] [PubMed] [Google Scholar]
  22. Szmuness W., Stevens C. E., Zang E. A., Harley E. J., Kellner A. A controlled clinical trial of the efficacy of the hepatitis B vaccine (Heptavax B): a final report. Hepatology. 1981 Sep-Oct;1(5):377–385. doi: 10.1002/hep.1840010502. [DOI] [PubMed] [Google Scholar]
  23. Villarejos V. M., Visoná K. A., Gutiérrez A., Rodríguez A. Role of saliva, urine and feces in the transmission of type B hepatitis. N Engl J Med. 1974 Dec 26;291(26):1375–1378. doi: 10.1056/NEJM197412262912602. [DOI] [PubMed] [Google Scholar]
  24. Viola L. A., Barrison I. G., Coleman J. C., Paradinas F. J., Fluker J. L., Evans B. A., Murray-Lyon I. M. Natural history of liver disease in chronic hepatitis B surface antigen carriers. Survey of 100 patients from Great Britain. Lancet. 1981 Nov 21;2(8256):1156–1159. doi: 10.1016/s0140-6736(81)90600-0. [DOI] [PubMed] [Google Scholar]
  25. Weller I. V., Bassendine M. F., Craxi A., Fowler M. J., Monjardino J., Thomas H. C., Sherlock S. Successful treatment of HBs and HBeAg positive chronic liver disease: prolonged inhibition of viral replication by highly soluble adenine arabinoside 5'-monophosphate (ARA-AMP). Gut. 1982 Sep;23(9):717–723. doi: 10.1136/gut.23.9.717. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Weller I. V., Fowler M. J., Monjardino J., Thomas H. C. The detection of HBV-DNA in serum by molecular hybridisation: a more sensitive method for the detection of complete HBV particles. J Med Virol. 1982;9(4):273–280. doi: 10.1002/jmv.1890090405. [DOI] [PubMed] [Google Scholar]

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