Abstract
Two hundred and forty four men with non-gonococcal urethritis (NGU) took part in a trial of minocycline. Chlamydiae were isolated from 34%, ureaplasmas from 47.1%, and Mycoplasma hominis from 10.2%. These micro-organisms were isolated least often from men suffering their third or more attack of NGU, and men in this group failed most often to respond to minocycline. Irrespective of the micro-organisms isolated originally or the number of previous attacks, the failure rate (10%) for men receiving minocycline for 10 days was significantly less than for those receiving this antibiotic for one or two days. More than half of the men suffering third attacks from whom micro-organisms were not isolated failed to respond to these short regimens. One of the lowest failure rates (4%) after short term treatment, however, was seen in men experiencing first attacks who yielded only ureaplasmas with or without M hominis, which indicates the importance of ureaplasmas in this group of patients. Chlamydiae were not reisolated from any patient after treatment, irrespective of its duration, and the only ureaplasmas that were reisolated were from nine patients who carried tetracycline resistant strains. Reasons for the absence of chlamydiae and ureaplasmas in the presence of disease and the need to look for other microorganisms as a cause of NGU are discussed among other issues raised by these results.
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Selected References
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- Bowie W. R., Alexander E. R., Stimson J. B., Floyd J. F., Holmes K. K. Therapy for nongonococcal urethritis: double-blind randomized comparison of two doses and two durations of minocycline. Ann Intern Med. 1981 Sep;95(3):306–311. doi: 10.7326/0003-4819-95-3-306. [DOI] [PubMed] [Google Scholar]
- Coufalik E. D., Taylor-Robinson D., Csonka G. W. Treatment of nongonococcal urethritis with rifampicin as a means of defining the role of Ureaplasma urealyticum. Br J Vener Dis. 1979 Feb;55(1):36–43. doi: 10.1136/sti.55.1.36. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fontaine E. A., Taylor-Robinson D., Hanna N. F., Coufalik E. D. Anaerobes in men with urethritis. Br J Vener Dis. 1982 Oct;58(5):321–326. doi: 10.1136/sti.58.5.321. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Grimble A. S., Amarasuriya K. L. Non-specific urethritis and the tetracyclines. Br J Vener Dis. 1975 Jun;51(3):198–205. doi: 10.1136/sti.51.3.198. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hawkins D. A., Taylor-Robinson D., Evans R. T., Furr P. M., Harris J. R. Unsuccessful treatment of non-gonococcal urethritis with rosoxacin provides information on the aetiology of the disease. Genitourin Med. 1985 Feb;61(1):51–55. doi: 10.1136/sti.61.1.51. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Holmes K. K., Johnson D. W., Floyd T. M. Studies of venereal disease. 3. Double-blind comparison of tetracycline hydrochloride and placebo in treatment of nongonococcal urethritis. JAMA. 1967 Nov 6;202(6):474–476. doi: 10.1001/jama.202.6.474. [DOI] [PubMed] [Google Scholar]
- Prentice M. J., Taylor-Robinson D., Csonka G. W. Non-specific urethritis. A placebo-controlled trial of minocycline in conjunction with laboratory investigations. Br J Vener Dis. 1976 Aug;52(4):269–275. doi: 10.1136/sti.52.4.269. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stimson J. B., Hale J., Bowie W. R., Holmes K. K. Tetracycline-resistant Ureaplasma urealyticum: a cause of persistent nongonococcal urethritis. Ann Intern Med. 1981 Feb;94(2):192–194. doi: 10.7326/0003-4819-94-2-192. [DOI] [PubMed] [Google Scholar]
- Taylor-Robinson D., Furr P. M., Hanna N. F. Microbiological and serological study of non-gonococcal urethritis with special reference to Mycoplasma genitalium. Genitourin Med. 1985 Oct;61(5):319–324. doi: 10.1136/sti.61.5.319. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Taylor-Robinson D., Furr P. M. Recovery and identification of human genital tract mycoplasmas. Isr J Med Sci. 1981 Jul;17(7):648–653. [PubMed] [Google Scholar]
- Taylor-Robinson D., Furr P. M. The static effect of rosaramicin on Ureaplasma urealyticum and the development of antibiotic resistance. J Antimicrob Chemother. 1982 Sep;10(3):185–191. doi: 10.1093/jac/10.3.185. [DOI] [PubMed] [Google Scholar]
- Taylor-Robinson D. Mycoplasma infections of the human urogenital tract with particular reference to non-gonococcal urethritis. Ann Microbiol (Paris) 1984 Jan-Feb;135A(1):129–134. doi: 10.1016/s0769-2609(84)80069-1. [DOI] [PubMed] [Google Scholar]
- Taylor-Robinson D., Thomas B. J. The rôle of Chlamydia trachomatis in genital-tract and associated diseases. J Clin Pathol. 1980 Mar;33(3):205–233. doi: 10.1136/jcp.33.3.205. [DOI] [PMC free article] [PubMed] [Google Scholar]