Abstract
The efficacy and tolerance of single oral doses of cefuroxime axetil (1.5 g) were compared with oral ampicillin (3 g) for treating acute gonococcal urethritis in 110 men and 30 women. Each dose was given with 1 g probenecid. Of the 62 assessable patients who received ampicillin, two failed to respond to treatment. Of 67 assessable patients who received cefuroxime axetil, one failed to respond. Pencillinase producing strains of Neisseria gonorrhoeae were isolated from five patients; one received ampicillin and failed to respond, whereas the other four received cefuroxime axetil and three were cured. A single oral dose of 1.5 g cefuroxime axetil with 1 g probenecid seemed to be an effective treatment for acute gonococcal urethritis, especially for penicillin resistant strains.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Fowler W., Rahim G., Brown J. D. Clinical experience in the use of cefuroxime in gonorrhoea. Br J Vener Dis. 1978 Dec;54(6):400–402. doi: 10.1136/sti.54.6.400. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Harding S. M., Williams P. E., Ayrton J. Pharmacology of Cefuroxime as the 1-acetoxyethyl ester in volunteers. Antimicrob Agents Chemother. 1984 Jan;25(1):78–82. doi: 10.1128/aac.25.1.78. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lossick J. G., Thompson S. E., Smeltzer M. P. Comparison of cefuroxime and penicillin in the treatment of uncomplicated gonorrhea. Antimicrob Agents Chemother. 1982 Sep;22(3):409–413. doi: 10.1128/aac.22.3.409. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McCutchan J. A., Adler M. W., Berrie J. R. Penicillinase-producing Neisseria gonorrhoeae in Great Britain, 1977-81: alarming increase in incidence and recent development of endemic transmission. Br Med J (Clin Res Ed) 1982 Jul 31;285(6338):337–340. doi: 10.1136/bmj.285.6338.337. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morrison G. D., Evans A. J., Haskins H. W., Lewis N. M., Seale G. H., Mayall E., Mullinger B. M. Cefuroxime compared with penicillin for the treatment of gonorrhea. Sex Transm Dis. 1980 Oct-Dec;7(4):188–190. doi: 10.1097/00007435-198010000-00009. [DOI] [PubMed] [Google Scholar]
- Verbrugh H. A., Peters R., Rozenberg-Arska M., Peterson P. K., Verhoef J. Antibodies to cell wall peptidoglycan of Staphylococcus aureus in patients with serious staphylococcal infections. J Infect Dis. 1981 Jul;144(1):1–9. doi: 10.1093/infdis/144.1.1. [DOI] [PubMed] [Google Scholar]
- van Embden J. D., van Klingeren B., Dessens-Kroon M., van Wijngaarden L. J. Emergence in the Netherlands of penicillinase-producing gonococci carrying "Africa" plasmid in combination with transfer plasmid. Lancet. 1981 Apr 25;1(8226):938–938. doi: 10.1016/s0140-6736(81)91630-5. [DOI] [PubMed] [Google Scholar]