Skip to main content
NCBI home page
Genitourinary Medicine logoLink to Genitourinary Medicine
. 1986 Dec;62(6):373–376. doi: 10.1136/sti.62.6.373

In vitro activity of selected antimicrobial agents against penicillinase producing Neisseria gonorrhoeae (PPNG) and non-PPNG strains.

D J Waghorn, B S Azadian, C Talboys
PMCID: PMC1012001  PMID: 2950043

Abstract

One hundred and twelve penicillinase producing Neisseria gonorrhoeae (PPNG) isolates and the same number of non-PPNG isolates were obtained from patients attending the genitourinary department of this hospital. Susceptibilities to six beta lactam antibiotics--ceftriaxone, cefotaxime, cefuroxime, ceftazidime, amoxycillin, and temocillin--to the combined formulation of amoxycillin and clavulanic acid, Augmentin, and to the aminocyclitol, spectinomycin, were compared by assessing their minimum inhibitory concentrations (MICs). Results showed that all the cephalosporins used in this study had good in vitro activity against both PPNG and non-PPNG strains, and ceftriaxone had the lowest MICs. Temocillin and Augmentin also showed good activity against both types of strain. Spectinomycin resistance was shown in about 4% of the PPNG isolates but was not found in any non-PPNG strains.

Full text

PDF
373

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adler M. W., McCutchan J. A. Survey of cases of gonorrhoea caused by penicillinase producing Neisseria gonorrhoeae in the United Kingdom. Genitourin Med. 1985 Feb;61(1):36–38. doi: 10.1136/sti.61.1.36. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Ashford W. A., Golash R. G., Hemming V. G. Penicillinase-producing Neisseria gonorrhoeae. Lancet. 1976 Sep 25;2(7987):657–658. doi: 10.1016/s0140-6736(76)92467-3. [DOI] [PubMed] [Google Scholar]
  3. Ashford W. A., Potts D. W., Adams H. J., English J. C., Johnson S. R., Biddle J. W., Thornsberry C., Jaffe H. W. Spectinomycin-resistant penicillinase-producing Neisseria gonorrhoeae. Lancet. 1981 Nov 7;2(8254):1035–1037. doi: 10.1016/s0140-6736(81)91227-7. [DOI] [PubMed] [Google Scholar]
  4. Barlow D., Phillips I. Cefotaxime in the treatment of gonorrhoea caused by beta-lactamase-producing Neisseria gonorrhoeae. J Antimicrob Chemother. 1984 Sep;14 (Suppl B):291–293. doi: 10.1093/jac/14.suppl_b.291. [DOI] [PubMed] [Google Scholar]
  5. Brown S., Warnnissorn T., Biddle J., Panikabutra K., Traisupa A. Antimicrobial resistance of Neisseria gonorrhoea in Bangkok: is single-drug treatment passé. Lancet. 1982 Dec 18;2(8312):1366–1368. doi: 10.1016/s0140-6736(82)91271-5. [DOI] [PubMed] [Google Scholar]
  6. Easmon C. S., Forster G. E., Walker G. D., Ison C. A., Harris J. R., Munday P. E. Spectinomycin as initial treatment for gonorrhoea. Br Med J (Clin Res Ed) 1984 Oct 20;289(6451):1032–1034. doi: 10.1136/bmj.289.6451.1032. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Easmon C. S., Ison C. A., Bellinger C. M., Harris J. W. Emergence of resistance after spectinomycin treatment for gonorrhoea due to beta-lactamase producing strain of Neisseria gonorrhoeae. Br Med J (Clin Res Ed) 1982 May 29;284(6329):1604–1605. doi: 10.1136/bmj.284.6329.1604. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Handsfield H. H., Murphy V. L. Comparative study of ceftriaxone and spectinomycin for treatment of uncomplicated gonorrhoea in men. Lancet. 1983 Jul 9;2(8341):67–70. doi: 10.1016/s0140-6736(83)90058-2. [DOI] [PubMed] [Google Scholar]
  9. Herzog C., Ison C. A., Easmon C. S. Antimicrobial sensitivity of Neisseria gonorrhoeae. Comparison of penicillinase producing and non-penicillinase producing strains. Br J Vener Dis. 1983 Oct;59(5):289–292. doi: 10.1136/sti.59.5.289. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Judson F. N., Ehret J. M., Root C. J. Comparative study of ceftriaxone and aqueous procaine penicillin G in the treatment of uncomplicated gonorrhea in women. Antimicrob Agents Chemother. 1983 Feb;23(2):218–220. doi: 10.1128/aac.23.2.218. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Kerbs S. B., Stone J. R., Jr, Berg S. W., Harrison W. O. In vitro antimicrobial activity of eight new beta-lactam antibiotics against penicillin-resistant Neisseria gonorrhoeae. Antimicrob Agents Chemother. 1983 Apr;23(4):541–544. doi: 10.1128/aac.23.4.541. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Key P. R., Azadian B. S., Evans B. A. Augmentin compared with amoxycillin in treating uncomplicated gonorrhoea. Genitourin Med. 1985 Jun;61(3):165–167. doi: 10.1136/sti.61.3.165. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Lawrence A. G., Shanson D. C. Single dose oral amoxycillin 3 g with either 125 mg or 250 mg clavulanic acid to treat uncomplicated anogenital gonorrhoea. Genitourin Med. 1985 Jun;61(3):168–171. doi: 10.1136/sti.61.3.168. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. McCormack W. M. Penicillinase-producing Neisseria gonorrhoeae--a retrospective. N Engl J Med. 1982 Aug 12;307(7):438–439. doi: 10.1056/NEJM198208123070712. [DOI] [PubMed] [Google Scholar]
  15. McCutchan J. A., Adler M. W., Berrie J. R. Penicillinase-producing Neisseria gonorrhoeae in Great Britain, 1977-81: alarming increase in incidence and recent development of endemic transmission. Br Med J (Clin Res Ed) 1982 Jul 31;285(6338):337–340. doi: 10.1136/bmj.285.6338.337. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Reyn A., Schmidt H., Trier M., Bentzon M. W. Spectinomycin hydrochloride (Trobicin) in the treatment of gonorrhoea. Observation of resistant strains of Neisseria gonorrhoeae. Br J Vener Dis. 1973 Feb;49(1):54–59. doi: 10.1136/sti.49.1.54. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Stolz E., Zwart H. G., Michel M. F. Activity of eight antimicrobial agents in vitro against N. Gonorrhoeae. Br J Vener Dis. 1975 Aug;51(4):257–264. doi: 10.1136/sti.51.4.257. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Thin R. N., Barlow D., Eykyn S., Phillips I. Imported penicillinase producing Neisseria gonorrhoeae becomes endemic in London. Br J Vener Dis. 1983 Dec;59(6):364–368. doi: 10.1136/sti.59.6.364. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Genitourinary Medicine are provided here courtesy of BMJ Publishing Group

RESOURCES