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. 1986 Dec;62(6):393–395. doi: 10.1136/sti.62.6.393

Squamous carcinoma of the anus in young homosexual men with T helper cell depletion.

L C Howard, S Paterson-Brown, J N Weber, S T Chan, J R Harris, G Glazer
PMCID: PMC1012006  PMID: 2950044

Abstract

Two cases of squamous carcinoma of the anus in white homosexual men aged 36 and 47 years are reported, each with a short history of rapidly enlarging perianal lesions. Immunological studies showed that both men had pronounced T helper lymphocyte depletion, and antibody to human T cell lymphotropic virus type III (HTLV-III) was detected in both patients. In addition one patient had a long history of wart virus infection of the anal canal. The diminished cellular immunity associated with HTLV-III may have been responsible for the development of the squamous carcinoma, either directly or by its association with human papilloma virus infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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