Abstract
OBJECTIVE--Man made mineral fibres imitate asbestos and produce tumours of the pleura in animals. To answer the question, Does prolonged exposure to fibreglass adversely affect pulmonary function or produce radiographic abnormalities in human subjects? we studied workers in a midwestern appliance plant where refrigerator doors and previously entire cabinets were insulated with fibreglass sheeting and loose rotary spun fibreglass. METHODS--Spirometry and lung volumes were measured, respiratory and occupational questionnaires were administered, and chest x-ray films were read for pneumoconiosis using International Labour Office (ILO) 1980 criteria in 284 workers with exposure of 20 years or more. RESULTS--Expiratory flows were reduced including FEV1 (mean 90.3% of predicted (pr), FEF25-75 (85.5% pr), and FEF75-85 (76.2% pr). Forced vital capacity was significantly reduced (92.8% pr) and total lung capacity was significantly increased (109.2% pr). In white male smokers, a group large enough for comparisons, parameters of pulmonary function were reduced further in the presence of irregular opacities. Forty three workers (15.1%) had evidence of pneumoconiosis on chest radiographs: 26 of these (9.1%), had no known exposure to asbestos and 17 (6.0%) had some exposure. The best judgement was that in 36 (13.0%), pulmonary opacities or pleural abnormalities were due to fibreglass. CONCLUSION--Commercial rotary spun fibreglass used for insulating appliances appears to produce human disease that is similar to asbestosis.
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- Botham S. K., Holt P. F. Comparison of effects of glass fibre and glass powder on guinea-pig lungs. Br J Ind Med. 1973 Jul;30(3):232–236. doi: 10.1136/oem.30.3.232. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Davis G. S., Brody A. R., Craighead J. E. Analysis of airspace and interstitial mononuclear cell populations in human diffuse interstitial lung disease. Am Rev Respir Dis. 1978 Jul;118(1):7–15. doi: 10.1164/arrd.1978.118.1.7. [DOI] [PubMed] [Google Scholar]
- Harris T. R., Pratt P. C., Kilburn K. H. Total lung capacity measured by roentgenograms. Am J Med. 1971 Jun;50(6):756–763. doi: 10.1016/0002-9343(71)90183-5. [DOI] [PubMed] [Google Scholar]
- Hill J. W., Whitehead W. S., Cameron J. D., Hedgecock G. A. Glass fibres: absence of pulmonary hazard in production workers. Br J Ind Med. 1973 Apr;30(2):174–179. doi: 10.1136/oem.30.2.174. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kilburn K. H., Lilis R., Anderson H. A., Miller A., Warshaw R. H. Interaction of asbestos, age, and cigarette smoking in producing radiographic evidence of diffuse pulmonary fibrosis. Am J Med. 1986 Mar;80(3):377–381. doi: 10.1016/0002-9343(86)90709-6. [DOI] [PubMed] [Google Scholar]
- Kilburn K. H., Warshaw R. H. Abnormal lung function associated with asbestos disease of the pleura, the lung, and both: a comparative analysis. Thorax. 1991 Jan;46(1):33–38. doi: 10.1136/thx.46.1.33. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kilburn K. H., Warshaw R. H. Difficulties of attribution of effect in workers exposed to fiberglass and asbestos. Am J Ind Med. 1991;20(6):745–751. doi: 10.1002/ajim.4700200605. [DOI] [PubMed] [Google Scholar]
- Kilburn K. H., Warshaw R. Pulmonary functional impairment associated with pleural asbestos disease. Circumscribed and diffuse thickening. Chest. 1990 Oct;98(4):965–972. doi: 10.1378/chest.98.4.965. [DOI] [PubMed] [Google Scholar]
- Kilburn K. H., Warshaw R., Thornton J. C. Pulmonary function in histology technicians compared with women from Michigan: effects of chronic low dose formaldehyde on a national sample of women. Br J Ind Med. 1989 Jul;46(7):468–472. doi: 10.1136/oem.46.7.468. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lee K. P., Barras C. E., Griffith F. D., Waritz R. S. Pulmonary response to glass fiber by inhalation exposure. Lab Invest. 1979 Feb;40(2):123–133. [PubMed] [Google Scholar]
- Miller A., Thornton J. C., Warshaw R., Bernstein J., Selikoff I. J., Teirstein A. S. Mean and instantaneous expiratory flows, FVC and FEV1: prediction equations from a probability sample of Michigan, a large industrial state. Bull Eur Physiopathol Respir. 1986 Nov-Dec;22(6):589–597. [PubMed] [Google Scholar]
- Nasr A. N., Ditchek T., Scholtens P. A. The prevalence of radiographic abnormalities in the chests of fiber glass workers. J Occup Med. 1971 Aug;13(8):371–376. [PubMed] [Google Scholar]
- Rossiter C. E., Weill H. Ethnic differences in lung function: evidence for proportional differences. Int J Epidemiol. 1974 Mar;3(1):55–61. doi: 10.1093/ije/3.1.55. [DOI] [PubMed] [Google Scholar]
- Stanton M. F., Wrench C. Mechanisms of mesothelioma induction with asbestos and fibrous glass. J Natl Cancer Inst. 1972 Mar;48(3):797–821. [PubMed] [Google Scholar]
- Weill H., Hughes J. M., Hammad Y. Y., Glindmeyer H. W., 3rd, Sharon G., Jones R. N. Respiratory health in workers exposed to man-made vitreous fibers. Am Rev Respir Dis. 1983 Jul;128(1):104–112. doi: 10.1164/arrd.1983.128.1.104. [DOI] [PubMed] [Google Scholar]
- Wright G. W. Airborne fibrous glass particles. Chest roentgenograms of persons with prolonged exposure. Arch Environ Health. 1968 Feb;16(2):175–181. doi: 10.1080/00039896.1968.10665040. [DOI] [PubMed] [Google Scholar]