Skip to main content
NCBI home page
British Journal of Industrial Medicine logoLink to British Journal of Industrial Medicine
. 1993 Aug;50(8):699–703. doi: 10.1136/oem.50.8.699

Angiosarcoma, porphyria cutanea tarda, and probable chloracne in a worker exposed to waste oil contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin.

R McConnell 1, K Anderson 1, W Russell 1, K E Anderson 1, R Clapp 1, E K Silbergeld 1, P J Landrigan 1
PMCID: PMC1012172  PMID: 8104464

Abstract

A worker developed angiosarcoma, porphyria cutanea tarda, and skin lesions characteristic of mild chloracne. About 10 years earlier he had been employed at a truck terminal in Saint Louis, Missouri, at a time when it was sprayed with waste oil contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The occurrence of these three rare conditions in a single exposed worker supports the aetiological relation between environmental exposure to TCDD and the subsequent development of soft tissue sarcoma and porphyria cutanea tarda.

Full text

PDF
699

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BLEIBERG J., WALLEN M., BRODKIN R., APPLEBAUM I. L. INDUSTRIALLY ACQUIRED PORPHYRIA. Arch Dermatol. 1964 Jun;89:793–797. doi: 10.1001/archderm.1964.01590300021006. [DOI] [PubMed] [Google Scholar]
  2. Bickers D. R. The dermatologic manifestations of human porphyria. Ann N Y Acad Sci. 1987;514:261–267. doi: 10.1111/j.1749-6632.1987.tb48781.x. [DOI] [PubMed] [Google Scholar]
  3. Carter C. D., Kimbrough R. D., Liddle J. A., Cline R. E., Zack M. M., Jr, Barthel W. F., Koehler R. E., Phillips P. E. Tetrachlorodibenzodioxin: an accidental poisoning episode in horse arenas. Science. 1975 May 16;188(4189):738–740. doi: 10.1126/science.1168366. [DOI] [PubMed] [Google Scholar]
  4. Chiba M., Sassa S. Analysis of porphyrin carboxylic acids in biological fluids by high-performance liquid chromatography. Anal Biochem. 1982 Aug;124(2):279–285. doi: 10.1016/0003-2697(82)90039-2. [DOI] [PubMed] [Google Scholar]
  5. Cripps D. J., Peters H. A., Gocmen A., Dogramici I. Porphyria turcica due to hexachlorobenzene: a 20 to 30 year follow-up study on 204 patients. Br J Dermatol. 1984 Oct;111(4):413–422. doi: 10.1111/j.1365-2133.1984.tb06603.x. [DOI] [PubMed] [Google Scholar]
  6. Elder G. H. Porphyrin metabolism in porphyria cutanea tarda. Semin Hematol. 1977 Apr;14(2):227–242. [PubMed] [Google Scholar]
  7. Fingerhut M. A., Halperin W. E., Marlow D. A., Piacitelli L. A., Honchar P. A., Sweeney M. H., Greife A. L., Dill P. A., Steenland K., Suruda A. J. Cancer mortality in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. N Engl J Med. 1991 Jan 24;324(4):212–218. doi: 10.1056/NEJM199101243240402. [DOI] [PubMed] [Google Scholar]
  8. Held J. L., Sassa S., Kappas A., Harber L. C. Erythrocyte uroporphyrinogen decarboxylase activity in porphyria cutanea tarda: a study of 40 consecutive patients. J Invest Dermatol. 1989 Sep;93(3):332–334. [PubMed] [Google Scholar]
  9. Hoffman R. E., Stehr-Green P. A., Webb K. B., Evans R. G., Knutsen A. P., Schramm W. F., Staake J. L., Gibson B. B., Steinberg K. K. Health effects of long-term exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. JAMA. 1986 Apr 18;255(15):2031–2038. [PubMed] [Google Scholar]
  10. McNulty W. P., Nielsen-Smith K. A., Lay J. O., Jr, Lippstreu D. L., Kangas N. L., Lyon P. A., Gross M. L. Persistence of TCDD in monkey adipose tissue. Food Chem Toxicol. 1982 Dec;20(6):985–986. doi: 10.1016/s0015-6264(82)80272-1. [DOI] [PubMed] [Google Scholar]
  11. Moses M., Prioleau P. G. Cutaneous histologic findings in chemical workers with and without chloracne with past exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Am Acad Dermatol. 1985 Mar;12(3):497–506. doi: 10.1016/s0190-9622(85)70070-9. [DOI] [PubMed] [Google Scholar]
  12. Patterson D. G., Jr, Hoffman R. E., Needham L. L., Roberts D. W., Bagby J. R., Pirkle J. L., Falk H., Sampson E. J., Houk V. N. 2,3,7,8-Tetrachlorodibenzo-p-dioxin levels in adipose tissue of exposed and control persons in Missouri. An interim report. JAMA. 1986 Nov 21;256(19):2683–2686. [PubMed] [Google Scholar]
  13. Pazderova-Vejlupková J., Lukás E., Nemcova M., Pícková J., Jirásek L. The development and prognosis of chronic intoxication by tetrachlordibenzo-p-dioxin in men. Arch Environ Health. 1981 Jan-Feb;36(1):5–11. doi: 10.1080/00039896.1981.10667598. [DOI] [PubMed] [Google Scholar]
  14. Poland A. P., Smith D., Metter G., Possick P. A health survey of workers in a 2,4-D and 2,4,5-T plan with special attention to chloracne, porphyria cutanea tarda, and psychologic parameters. Arch Environ Health. 1971 Mar;22(3):316–327. doi: 10.1080/00039896.1971.10665850. [DOI] [PubMed] [Google Scholar]
  15. Saracci R., Kogevinas M., Bertazzi P. A., Bueno de Mesquita B. H., Coggon D., Green L. M., Kauppinen T., L'Abbé K. A., Littorin M., Lynge E. Cancer mortality in workers exposed to chlorophenoxy herbicides and chlorophenols. Lancet. 1991 Oct 26;338(8774):1027–1032. doi: 10.1016/0140-6736(91)91898-5. [DOI] [PubMed] [Google Scholar]
  16. Sassa S., de Verneuil H., Anderson K. E., Kappas A. Purification and properties of human erythrocyte uroporphyrinogen decarboxylase: immunological demonstration of the enzyme defect in porphyria cutanea tarda. Trans Assoc Am Physicians. 1983;96:65–75. [PubMed] [Google Scholar]
  17. Schwartz S., Edmondson P., Stephenson B., Sarkar D., Freyholtz H. Direct spectrofluorophotometric determination of porphyrin in diluted urine. Ann Clin Res. 1976;8 (Suppl 17):156–161. [PubMed] [Google Scholar]
  18. Smith S. G. The use of thin layer chromatography in the separation of free porphyrins and porphyrin methyl esters. Br J Dermatol. 1975 Sep;93(3):291–295. doi: 10.1111/j.1365-2133.1975.tb06494.x. [DOI] [PubMed] [Google Scholar]
  19. Suskind R. R., Hertzberg V. S. Human health effects of 2,4,5-T and its toxic contaminants. JAMA. 1984 May 11;251(18):2372–2380. [PubMed] [Google Scholar]
  20. Taylor J. S. Environmental chloracne: update and overview. Ann N Y Acad Sci. 1979 May 31;320:295–307. [PubMed] [Google Scholar]
  21. Woods J. S., Polissar L., Severson R. K., Heuser L. S., Kulander B. G. Soft tissue sarcoma and non-Hodgkin's lymphoma in relation to phenoxyherbicide and chlorinated phenol exposure in western Washington. J Natl Cancer Inst. 1987 May;78(5):899–910. [PubMed] [Google Scholar]

Articles from British Journal of Industrial Medicine are provided here courtesy of BMJ Publishing Group

RESOURCES