Skip to main content
NCBI home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1992 Oct;51(10):1149–1151. doi: 10.1136/ard.51.10.1149

Treatment of severe thrombocytopenia in systemic lupus erythematosus with intravenous gammaglobulin.

E J ter Borg 1, C G Kallenberg 1
PMCID: PMC1012421  PMID: 1280073

Abstract

Three patients with lupus with severe auto-immune thrombocytopenia were treated with high doses of intravenous gammaglobulin. In the patient with active disease a prolonged but partial response with respect to platelet counts was observed. In the two other patients who had no disease activity other than thrombocytopenia at the time of intravenous gammaglobulin treatment a minor (and only transient) increase in platelet counts was seen after treatment. No change in the state of disease activity nor in the levels of antinuclear antibodies, circulating immune complexes, nor complement C3/4 was observed in these three patients after treatment with intravenous gammaglobulin.

Full text

PDF
1149

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Akashi K., Nagasawa K., Mayumi T., Yokota E., Oochi N., Kusaba T. Successful treatment of refractory systemic lupus erythematosus with intravenous immunoglobulins. J Rheumatol. 1990 Mar;17(3):375–379. [PubMed] [Google Scholar]
  2. Bussel J. B., Hilgartner M. W. The use and mechanism of action of intravenous immunoglobulin in the treatment of immune haematologic disease. Br J Haematol. 1984 Jan;56(1):1–7. doi: 10.1111/j.1365-2141.1984.tb01266.x. [DOI] [PubMed] [Google Scholar]
  3. Bussel J., Pahwa S., Porges A., Cunningham-Rundles S., Koziner B., Morell A., Barandun S. Correlation of in vitro antibody synthesis with the outcome of intravenous gamma-globulin treatment of chronic idiopathic thrombocytopenic purpura. J Clin Immunol. 1986 Jan;6(1):50–56. doi: 10.1007/BF00915364. [DOI] [PubMed] [Google Scholar]
  4. Delfraissy J. F., Tchernia G., Laurian Y., Wallon C., Galanaud P., Dormont J. Suppressor cell function after intravenous gammaglobulin treatment in adult chronic idiopathic thrombocytopenic purpura. Br J Haematol. 1985 Jun;60(2):315–322. doi: 10.1111/j.1365-2141.1985.tb07417.x. [DOI] [PubMed] [Google Scholar]
  5. Fehr J., Hofmann V., Kappeler U. Transient reversal of thrombocytopenia in idiopathic thrombocytopenic purpura by high-dose intravenous gamma globulin. N Engl J Med. 1982 May 27;306(21):1254–1258. doi: 10.1056/NEJM198205273062102. [DOI] [PubMed] [Google Scholar]
  6. Frank M. M., Hamburger M. I., Lawley T. J., Kimberly R. P., Plotz P. H. Defective reticuloendothelial system Fc-receptor function in systemic lupus erythematosus. N Engl J Med. 1979 Mar 8;300(10):518–523. doi: 10.1056/NEJM197903083001002. [DOI] [PubMed] [Google Scholar]
  7. Imbach P., Barandun S., d'Apuzzo V., Baumgartner C., Hirt A., Morell A., Rossi E., Schöni M., Vest M., Wagner H. P. High-dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura in childhood. Lancet. 1981 Jun 6;1(8232):1228–1231. doi: 10.1016/s0140-6736(81)92400-4. [DOI] [PubMed] [Google Scholar]
  8. Kurata Y., Tsubakio T., Yonezawa T., Tarui S. High-dose gammaglobulin therapy for idiopathic thrombocytopenic purpura in adults. Acta Haematol. 1983;69(6):391–397. doi: 10.1159/000206927. [DOI] [PubMed] [Google Scholar]
  9. Leung D. Y., Burns J. C., Newburger J. W., Geha R. S. Reversal of lymphocyte activation in vivo in the Kawasaki syndrome by intravenous gammaglobulin. J Clin Invest. 1987 Feb;79(2):468–472. doi: 10.1172/JCI112835. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lin R. Y., Racis S. P. In vivo reduction of circulating C1q binding immune complexes by intravenous gammaglobulin administration. Int Arch Allergy Appl Immunol. 1986;79(3):286–290. doi: 10.1159/000233988. [DOI] [PubMed] [Google Scholar]
  11. Maier W. P., Gordon D. S., Howard R. F., Saleh M. N., Miller S. B., Lieberman J. D., Woodlee P. M. Intravenous immunoglobulin therapy in systemic lupus erythematosus-associated thrombocytopenia. Arthritis Rheum. 1990 Aug;33(8):1233–1239. doi: 10.1002/art.1780330825. [DOI] [PubMed] [Google Scholar]
  12. Tsubakio T., Kurata Y., Katagiri S., Kanakura Y., Tamaki T., Kuyama J., Kanayama Y., Yonezawa T., Tarui S. Alteration of T cell subsets and immunoglobulin synthesis in vitro during high dose gamma-globulin therapy in patients with idiopathic thrombocytopenic purpura. Clin Exp Immunol. 1983 Sep;53(3):697–702. [PMC free article] [PubMed] [Google Scholar]
  13. Winiarski J., Kreuger A., Ejderhamn J., Holm G. High dose intravenous IgG reduces platelet associated immunoglobulins and complement in idiopathic thrombocytopenic purpura. Scand J Haematol. 1983 Oct;31(4):342–348. doi: 10.1111/j.1600-0609.1983.tb00662.x. [DOI] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES