Skip to main content
PMC home page
Journal of Medical Genetics logoLink to Journal of Medical Genetics
. 1979 Dec;16(6):423–427. doi: 10.1136/jmg.16.6.423

Hereditary aspects of duodenal ulceration: pepsin 1 secretion in relation to ABO blood groups and ABH secretor status.

L Waft, N B Roberts, W H Taylor
PMCID: PMC1012586  PMID: 119857

Abstract

Pepsin 1, the ulcer-associated pepsin, occurred significantly more frequently in the gastric juice of those patients with duodenal ulcer who did not secrete A, B, or H antigens into gastric juice than in those secreting these antigens. This observation may explain the increased proportion of such non-secretors among patients with duodenal ulceration. In patients with gastric ulcer and non-ulcer dyspepsia, and in a miscellaneous group of patients, there was no association of pepsin 1 secretion with secretor status, suggesting that the association noted in duodenal ulceration is an indirect rather than a direct one. No increase of pepsin 1 occurred in group O patients with peptic ulcer, so that the increased proportion of such patients in peptic ulcer does not arise from differences in pepsin 1 secretion.

Full text

PDF
423

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baron J. H., Gutierrez L. V., Spencer J., Tinker J., Welbourn R. B. The insulin test in the unoperated subject. Gut. 1969 Dec;10(12):1046–1047. [PubMed] [Google Scholar]
  2. Berstad A. Inhibition of peptic activity in man by carbenoxolyne sodium. Scand J Gastroenterol. 1972;7(2):129–135. [PubMed] [Google Scholar]
  3. EVANS D. A., MCCONNELL R. B., DONOHOE W. T. FUCOSE AND AGGLUTINOGEN CONTENTS OF URINE FROM PATIENTS WITH DUODENAL ULCERS. J Lab Clin Med. 1964 Oct;64:581–593. [PubMed] [Google Scholar]
  4. Etherington D. J., Taylor W. H. Nomenclature of the pepsins. Nature. 1967 Oct 21;216(5112):279–280. doi: 10.1038/216279a0. [DOI] [PubMed] [Google Scholar]
  5. Etherington D. J., Taylor W. H. The pepsins of normal human gastric juice. Biochem J. 1969 Jul;113(4):663–668. doi: 10.1042/bj1130663. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. HANLEY W. B. HEREDITARY ASPECTS OF DUODENAL ULCERATION: SERUM-PEPSINOGEN LEVEL IN RELATION TO ABO BLOOD GROUPS AND SALIVARY ABH SECRETOR STATUS. Br Med J. 1964 Apr 11;1(5388):936–940. doi: 10.1136/bmj.1.5388.936. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. PEEBLES BROWN D. A., MELROSE A. G., WALLACE J. The blood groups in peptic ulceration. Br Med J. 1956 Jul 21;2(4985):135–138. doi: 10.1136/bmj.2.4985.135. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Roberts N. B., Taylor W. H. The inactivation by carbenoxolone of individual human pepsinogens and pepsins. Clin Sci Mol Med. 1973 Aug;45(2):213–224. doi: 10.1042/cs0450213. [DOI] [PubMed] [Google Scholar]
  9. Roberts N. B., Taylor W. H. The preparation and purification of individual human pepsins by using diethylaminoethyl-cellulose. Biochem J. 1978 Mar 1;169(3):607–615. doi: 10.1042/bj1690607. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. SIEVERS M. L. Hereditary aspects of gastric secretory function; race and ABO blood groups in relationship to acid and pepsin production. Am J Med. 1959 Aug;27:246–255. doi: 10.1016/0002-9343(59)90345-6. [DOI] [PubMed] [Google Scholar]
  11. Taylor W. H. Pepsins of patients with peptic ulcer. Nature. 1970 Jul 4;227(5253):76–77. doi: 10.1038/227076a0. [DOI] [PubMed] [Google Scholar]
  12. VENTZKE L. E., GROSSMAN M. I. Response of patients with duodenal ulcer to augmented histamine test as related to blood groups and to secretor status. Gastroenterology. 1962 Mar;42:292–294. [PubMed] [Google Scholar]
  13. Wright C. L., Shaw B., Sanders D. J., Reed J. D. Variation in the proportions of individual pepsins secreted by the cat in response to vagal stimulation and hypoglycaemia. Clin Sci Mol Med. 1975 Apr;48(4):297–305. doi: 10.1042/cs0480297. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Medical Genetics are provided here courtesy of BMJ Publishing Group

RESOURCES