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. 1979 Aug;16(4):246–253. doi: 10.1136/jmg.16.4.246

Use of chromosomal translocations with in situ DNA hybridisation to confirm localisation of human 5S ribosomal RNA genes.

S J Fennell, S Malcolm, R Williamson, M A Ferguson-Smith
PMCID: PMC1012664  PMID: 490577

Abstract

Two cases of chromosomal translocations involving the long arm of chromosome 1 were investigated for 5S ribosomal gene localisation using in situ hybridisation. In the first family, there was an interstitial translocation of 1q25-32 to chromosome 5; the 5S genes remained on chromosome 1. In the second family, there was a translocation of 1q42-44 to chromosome 21q12; the 5S gene locus in this case was translocated. This shows that the 5S ribosomal genes are at position 1q42-44, confirming a previous assignment based on adenovirus-induced uncoiling and on a partial trisomy (Steffensen et al., 1977).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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