Skip to main content
PMC home page
Journal of Medical Genetics logoLink to Journal of Medical Genetics
. 1973 Mar;10(1):85–89. doi: 10.1136/jmg.10.1.85

Monozygotic Twins with Ring Chromosome 22

R H Lindenbaum 1, M Bobrow 1, L Barber 1
PMCID: PMC1012981  PMID: 4697858

Abstract

Mentally retarded and monozygous twin sisters, with little physical abnormality, are described. Each twin carried a small ring chromosome, identified as a number 22.

Full text

PDF
85

Images in this article

86Image
on p.86
87Image
on p.87

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Al-Aish M. S., De la Cruz F., Goldsmith L. A., Volpe J., Mella G., Robinson J. C. Autosomal monosomy in man. Complete monosomy G (21-22) in a four-and-one-half-year-old mentally retarded girl. N Engl J Med. 1967 Oct 12;277(15):777–784. doi: 10.1056/NEJM196710122771502. [DOI] [PubMed] [Google Scholar]
  2. Atkins L., Sceery R. T., Keenan M. E. An unstable ring chromosome in a female infant with hypotonia, seizures, and retarded development. J Med Genet. 1966 Jun;3(2):134–138. doi: 10.1136/jmg.3.2.134. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Benson P. F., Taylor A. I., Gough M. H. Chromosome anomalies in primary lymphoedema. Lancet. 1967 Mar 4;1(7488):461–462. doi: 10.1016/s0140-6736(67)91088-4. [DOI] [PubMed] [Google Scholar]
  4. Blank C. E., Lorber J. A patient with 45,XX,Gminus-46,XX,Gr mosaicism. J Med Genet. 1969 Jun;6(2):220–223. doi: 10.1136/jmg.6.2.220. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Burgio G. R., Severi F., Rossoni R., Vaccaro R. Autoantibodies in Down's syndrome. Lancet. 1966 Feb 26;1(7435):497–498. doi: 10.1016/s0140-6736(66)91511-x. [DOI] [PubMed] [Google Scholar]
  6. Challacombe D. N., Taylor A. Monosomy for a G autosome. Arch Dis Child. 1969 Feb;44(233):113–119. doi: 10.1136/adc.44.233.113. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Crandall B. F., Weber F., Muller H. M., Burwell J. K. Identification of 21r and 22r chromosomes by quinacrine fluorescence. Clin Genet. 1972;3(4):264–270. doi: 10.1111/j.1399-0004.1972.tb04275.x. [DOI] [PubMed] [Google Scholar]
  8. Dubowitz V., Cooke P., Colver D., Harris F. Mental retardation, unusual facies, and abnormal nails associated with a group-G ring chromosome. A case report on two unrelated cases. J Med Genet. 1971 Jun;8(2):195–201. doi: 10.1136/jmg.8.2.195. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Gripenberg U., Elfving J., Gripenberg L. A 45,XX,21--child: attempt at a cytological and clinical interpretation of the karyotype. J Med Genet. 1972 Mar;9(1):110–115. doi: 10.1136/jmg.9.1.110. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. LEJEUNE J., BERGER R., RETHORE M. O., ARCHAMBAULT L., JEROME H., THIEFFRY S., AICARDI J., BROYER M., LAFOURCADE J., CRUVEILLER J. MONOSOMIE PARTIELLE POUR UN PETIT ACROCENTRIQUE. C R Hebd Seances Acad Sci. 1964 Nov 30;259:4187–4190. [PubMed] [Google Scholar]
  11. Nevin N. C., MacLaverty B., Campbell W. A. A child with a ring G chromosome (46,XX, Gr). J Med Genet. 1971 Jun;8(2):231–234. doi: 10.1136/jmg.8.2.231. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Reisman L. E., Darnell A., Murphy J. W., Hall B., Kasahara S. A child with partial deletion of a G-group autosome. Am J Dis Child. 1967 Sep;114(3):336–339. doi: 10.1001/archpedi.1967.02090240150018. [DOI] [PubMed] [Google Scholar]
  13. Reisman L. E., Kashara S., Chung C. Y., Darnell A., Hall B. Anti-mongolism. Studies in an infant with a partial monosomy of the 21 chromosome. Lancet. 1966 Feb 19;1(7434):394–397. doi: 10.1016/s0140-6736(66)91391-2. [DOI] [PubMed] [Google Scholar]
  14. Richards B. W., Rundle A. T., Hatton W. M., Stewart A. G-group ring chromosome in a mentally subnormal girl. J Ment Defic Res. 1971 Mar;15(1):61–72. doi: 10.1111/j.1365-2788.1971.tb01142.x. [DOI] [PubMed] [Google Scholar]
  15. Say B., Tunçbilek E., Yamak B., Balci S. An unusual chromosomal aberration in a case of Chediak-Higashi syndrome. J Med Genet. 1970 Dec;7(4):417–421. doi: 10.1136/jmg.7.4.417. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Seabright M. A rapid banding technique for human chromosomes. Lancet. 1971 Oct 30;2(7731):971–972. doi: 10.1016/s0140-6736(71)90287-x. [DOI] [PubMed] [Google Scholar]
  17. Summitt R. L. Cytogenetics in mentally defective children with anomalies: a controlled study. J Pediatr. 1969 Jan;74(1):58–66. doi: 10.1016/s0022-3476(69)80008-9. [DOI] [PubMed] [Google Scholar]
  18. Thorburn M. J., Johnson B. E. Apparent monosomy of a G autosome in a Jamaican infant. J Med Genet. 1966 Dec;3(4):290–292. doi: 10.1136/jmg.3.4.290. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Tulloch W. S., Newsam J. E. Studies on human meiotic chromosomes from testicular tissue. Lancet. 1966 Mar 26;1(7439):679–682. doi: 10.1016/s0140-6736(66)91627-8. [DOI] [PubMed] [Google Scholar]
  20. Weleber R. G., Hecht F., Giblett E. R. Ring-G chromosome, a new G-deletion syndrome? Am J Dis Child. 1968 Apr;115(4):489–493. doi: 10.1001/archpedi.1968.02100010491015. [DOI] [PubMed] [Google Scholar]
  21. Zdansky R., Bühler E. M., Vest M., Bühler U. K., Stalder G. Familiäres Mosaik mit G-Ring. Humangenetik. 1969;7(4):275–286. doi: 10.1007/BF00283550. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Medical Genetics are provided here courtesy of BMJ Publishing Group

RESOURCES