Skip to main content
Journal of Medical Genetics logoLink to Journal of Medical Genetics
. 1973 Jun;10(2):142–143. doi: 10.1136/jmg.10.2.142

Origin of 48,XXXY: The Evidence of the Xg Blood Groups

R A Pfeiffer *, Ruth Sanger
PMCID: PMC1013004  PMID: 4714580

Abstract

A third family is reported in which the Xg groups give information about the origin of an XXXY member: successive non-disjunction at the first and second paternal meiotic divisions is much the most likely cause. In the two previous informative families successive non-disjunction at maternal meiotic divisions was the most likely cause. An enquiry showed the average age of 29 fathers at the birth of XXXY sons to be 32-41 years.

Full text

PDF
142

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BLANK C. E. Apert's syndrome (a type of acrocephalosyndactyly)-observations on a British series of thirty-nine cases. Ann Hum Genet. 1960 May;24:151–164. doi: 10.1111/j.1469-1809.1959.tb01728.x. [DOI] [PubMed] [Google Scholar]
  2. DELACHAPELLE A., HORTLING H., SANGER R., RACE R. R. SUCCESSIVE NON-DISJUNCTION AT FIRST AND SECOND MEIOTIC DIVISION OF SPERMATOGENESIS: EVIDENCE OF CHROMOSOMES AND XG. Cytogenetics. 1964;3:334–341. doi: 10.1159/000129822. [DOI] [PubMed] [Google Scholar]
  3. Greenstein R. M., Harris D. J., Luzzatti L., Cann H. M. Cytogenetic analysis of a boy with the XXXY syndrome: origin of the X-chromosomes. Pediatrics. 1970 Apr;45(4):677–686. [PubMed] [Google Scholar]
  4. Sanger R., Tippett P., Gavin J. Xg groups and sex abnormalities in people of northern European ancestry. J Med Genet. 1971 Dec;8(4):417–426. doi: 10.1136/jmg.8.4.417. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Medical Genetics are provided here courtesy of BMJ Publishing Group

RESOURCES