Abstract
The sibs and parents of 83 Au-positive blood donors were tested in order to study the possible family clustering of Au positives in a population with a low frequency of carriers of Australia (Au) antigen. Tested by counterelectrophoresis the incidence of Au antigen in the parents of Au-positive persons is 5·4% and in the sibs 17·9%, compared to 0·15% in blood donors.
The hypothesis that the Au-carrier state is genetically determined was tested by calculating the proportion of Au-positive children in the families. The results are not inconsistent with a recessive mode of inheritance but do not allow definitive conclusions to be drawn.
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Selected References
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- Blumberg B. S., Friedlaender J. S., Woodside A., Sutnick A. I., London W. T. Hepatitis and Australia antigen: autosomal recessive inheritance of susceptibility to infection in humans. Proc Natl Acad Sci U S A. 1969 Apr;62(4):1108–1115. doi: 10.1073/pnas.62.4.1108. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Blumberg B. S., Melartin L., Guint R. A., Werner B. Family studies of a human serum isoantigen system (Australia antigen). Am J Hum Genet. 1966 Nov;18(6):594–608. [PMC free article] [PubMed] [Google Scholar]
- Carbonara A. O., Trinchieri G., Bedarida G., Filippi G. A Caucasian population with a high frequency of Au 'carriers': genetic analysis of the condition. Vox Sang. 1970 Sep-Oct;19(3):288–294. doi: 10.1111/j.1423-0410.1970.tb01528.x. [DOI] [PubMed] [Google Scholar]
- Iwarson S., Lindholm A., Lundin P., Hermodsson S. Hepatitis-associated antigen and antibody in Swedish blood donors. Relation to liver disease. Vox Sang. 1972;22(6):501–509. doi: 10.1111/j.1423-0410.1972.tb04637.x. [DOI] [PubMed] [Google Scholar]
- Lous P., Skinhoj P., Olesen H. HAA-antigen determination in 12,000 patients in a general Copenhagen hospital. Vox Sang. 1970 Sep-Oct;19(3):379–383. doi: 10.1111/j.1423-0410.1970.tb01543.x. [DOI] [PubMed] [Google Scholar]
- Melartin L., Myllylä G., Penttinen K. Detection of Au(1) antigen by immunodiffusion and platelet aggregation tests. Vox Sang. 1970 Sep-Oct;19(3):239–245. doi: 10.1111/j.1423-0410.1970.tb01519.x. [DOI] [PubMed] [Google Scholar]