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Journal of Medical Genetics logoLink to Journal of Medical Genetics
. 1973 Dec;10(4):340–345. doi: 10.1136/jmg.10.4.340

Genetic Association in Myocardial Infarction: Ethnicity; ABO, Rh, Lea, Xga Blood Groups; G6PD Deficiency; and Abnormal Haemoglobins

N Saha 1,2,*, C C S Toh 1,2, M B Ghosh 1,2,
PMCID: PMC1013053  PMID: 4204387

Abstract

Four hundred and eighty-six patients with myocardial infarction of both sexes comprising 213 Chinese, 53 Malays, 199 Indians, and 21 Europeans, resident in Singapore were investigated for differences in relative incidence, and for the ABO, Rh, Lea, and Xga blood groups, G6PD deficiency, and haemoglobin types. Relative incidence of myocardial infarction was appreciably higher among Indians than Chinese and Malays in all age groups, more so in younger people. There was no significant difference in the distribution of the genetic markers between patient and control series in either Chinese, Malays, or Indians.

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Selected References

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  1. BRONTE-STEWART B., BOTHA M. C., KRUT L. H. ABO blood groups in relation to ischaemic heart disease. Br Med J. 1962 Jun 16;1(5293):1646–1650. doi: 10.1136/bmj.1.5293.1646. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BRONTE-STEWART B. The effect of dietary fats on the blood lipids and their relation to ischaemic heart disease. Br Med Bull. 1958 Sep;14(3):243–252. doi: 10.1093/oxfordjournals.bmb.a069691. [DOI] [PubMed] [Google Scholar]
  3. Banerjee B., Saha N. Energy cost of some common daily activities of active tropical male and female subjects. J Appl Physiol. 1970 Aug;29(2):200–203. doi: 10.1152/jappl.1970.29.2.200. [DOI] [PubMed] [Google Scholar]
  4. Banerjee B., Tan P. Y., Saha N. Calorie and nutrient intake of pregnant Asian women. Trop Geogr Med. 1972 Sep;24(3):249–252. [PubMed] [Google Scholar]
  5. CHAN K. T. The ABO blood group frequency distribution of Singapore based on a blood donor sample. Singapore Med J. 1962 Mar;3:3–15. [PubMed] [Google Scholar]
  6. CHONG Y. H. Serum lipids and lipoproteins in healthy Malayans. Med J Malaya. 1961 Dec;16:136–143. [PubMed] [Google Scholar]
  7. Carlson L. A., Böttiger L. E. Ischaemic heart-disease in relation to fasting values of plasma triglycerides and cholesterol. Stockholm prospective study. Lancet. 1972 Apr 22;1(7756):865–868. doi: 10.1016/s0140-6736(72)90738-6. [DOI] [PubMed] [Google Scholar]
  8. Carter C. O. Genetics in the aetiology of disease. Lancet. 1969 May 17;1(7603):1014–1016. doi: 10.1016/s0140-6736(69)91810-8. [DOI] [PubMed] [Google Scholar]
  9. Chong Y. H., Soh C. C., Ho G. S., Rajaratnam R., Nonis P. Serum low density lipoproteins, triglycerides and cholesterol levels in Malaysia. Clin Chim Acta. 1971 Aug;34(1):85–92. doi: 10.1016/0009-8981(71)90070-2. [DOI] [PubMed] [Google Scholar]
  10. DANARAJ T. J., ACKER M. S., DANARAJ W., WONG H. O., TAN B. Y. Ethnic group differences in coronary heart disease in Singapore: an analysis of necropsy records. Am Heart J. 1959 Oct;58:516–526. doi: 10.1016/0002-8703(59)90085-7. [DOI] [PubMed] [Google Scholar]
  11. DAVIES T. A., WILLSHER J. D. Plasma cholesterol levels in first, second and third generation Chinese and Tamil Indians in Singapore. Med J Malaya. 1961 Mar;15:97–101. [PubMed] [Google Scholar]
  12. Kane S. P., Nye F. J. E.B.-virus antibody in Crohn's disease. Lancet. 1971 Jan 30;1(7692):233–233. doi: 10.1016/s0140-6736(71)90967-6. [DOI] [PubMed] [Google Scholar]
  13. Kannel W. B., Castelli W. P., McNamara P. M. The coronary profile: 12-year follow-up in the Framingham study. J Occup Med. 1967 Dec;9(12):611–619. [PubMed] [Google Scholar]
  14. LAU K. S., LOPEZ C. G., GAN O. M. Serum cholesterol levels in Malays, Indians and Chinese in Malaya. Med J Malaya. 1962 Mar;16:184–192. [PubMed] [Google Scholar]
  15. Langman M. J., Elwood P. C., Foote J., Ryrie D. R. ABO and Lewis blood-groups and serum-cholesterol. Lancet. 1969 Sep 20;2(7621):607–609. doi: 10.1016/s0140-6736(69)90323-7. [DOI] [PubMed] [Google Scholar]
  16. MALMROS H., WIGAND G. The effect on serum-cholesterol of diets containing different fats. Lancet. 1957 Jul 6;273(6984):1–7. doi: 10.1016/s0140-6736(57)90568-8. [DOI] [PubMed] [Google Scholar]
  17. PADMAVATI S., GUPTA S., PANTULU G. V. Dietary fat, serum cholesterol levels and incidence of atherosclerosis in Delhi. Circulation. 1959 Jun;19(6):849–855. doi: 10.1161/01.cir.19.6.849. [DOI] [PubMed] [Google Scholar]
  18. Saha N., Banerjee B. Erythrocyte G-6-PD deficiency among Chinese and Malays of Singapore. Trop Geogr Med. 1971 Jun;23(2):141–144. [PubMed] [Google Scholar]
  19. Saha N., Banerjee B. Incidence of abnormal haemoglobins in different ethnic groups of Indians. Humangenetik. 1971;11(4):300–303. doi: 10.1007/BF00278657. [DOI] [PubMed] [Google Scholar]
  20. Saha N., Banerjee B. Xga blood group in Chinese, Malays and Indians in Singapore. Vox Sang. 1973;24(6):542–544. doi: 10.1111/j.1423-0410.1973.tb03497.x. [DOI] [PubMed] [Google Scholar]
  21. Saha N. Incidence of G6PD deficiency in patients of three different ethnic groups suffering from pulmonary tuberculosis. J Med Genet. 1969 Sep;6(3):292–293. doi: 10.1136/jmg.6.3.292. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Saha N. Prevalence of abnormal haemoglobins in pulmonary tuberculosis in three different ethnic groups. J Med Genet. 1970 Mar;7(1):44–46. doi: 10.1136/jmg.7.1.44. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Sarvotham S. G., Berry J. N. Prevalence of coronary heart disease in an urban population in northern India. Circulation. 1968 Jun;37(6):939–953. doi: 10.1161/01.cir.37.6.939. [DOI] [PubMed] [Google Scholar]
  24. Srivastava D. K., Thakur C. P., Das M. ABO-blood groups in relation to ischaemic heart disease. Indian Heart J. 1966 Apr;18(2):140–149. [PubMed] [Google Scholar]
  25. Wysham D. N., Kohli K. C., Mulholland S. Coronary risk factors in Northern India. Am Heart J. 1970 Feb;79(2):181–187. doi: 10.1016/0002-8703(70)90307-8. [DOI] [PubMed] [Google Scholar]

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