Fig. 3.

Secondary clinical and MRI outcomes (panels A–H). Plotted values for panels A–F denote change in a given outcome for each treatment arm as derived from a linear mixed model. Change was measured according to the mean of a given outcome between baseline and end of study using all available data. The shaded regions denote the 95% confidence intervals of the estimated slope for a given outcome for each treatment arm. For panels G–H, the plotted values denote the estimated rate of new lesions by treatment arm and associated 95% CI. Abbreviations: MSFC (Multiple Sclerosis Functional Composite); T25FW (Timed 25-Foot Walk Test); 9HPT (Nine-hole Peg Test); nBPV (normalised Brain Parenchymal Volume); PASAT 3 (Paced Auditory Serial Addition Test – 3 second); Gd+ (Gadolinium-positive).