Table 1.
Baseline characteristics of participants.
| Characteristic | Vitamin D3 600 IU/day (n = 83) |
Vitamin D3 5000 IU/day (n = 89) |
|---|---|---|
| Age, mean ± SD | 34.2 (7.7) | 34.5 (7.1) |
| Female gender, n (%) | 70 (84) | 61 (69) |
| Race, n (%) | ||
| White/Caucasian | 61 (73) | 71 (80) |
| Black/African American | 18 (22) | 11 (12) |
| Other | 3 (3.6) | 5 (5.6) |
| Race not reported | 1 (1.2) | 2 (2.2) |
| Hispanic or Latino ethnicity, n (%) | 12 (15) | 18 (20) |
| Ethnicity not reported | 1 (1.2) | 0 (0) |
| Body Mass Index (kg/m2),a mean ± SD | 30.6 (9.4) | 28.7 (6.3) |
| EDSS, median (interquartile range) | 2.0 (1.0–2.5) | 2.0 (1.5–2.5) |
| T2-weighted lesion volume (ml),b mean ± SD | 3.7 (8.9) | 2.7 (3.5) |
| Brain volume (ml),c mean ± SD | 1488.3 (107.0) | 1496.1 (88.0) |
| Grey matter volume (ml),c median (interquartile range) | 772.7 (735.4–809.2) | 781.5 (737.8–808.0) |
| 25-hydroxyvitamin D level, ng/ml,d mean ± SD | 28.3 (9.9) | 29.6 (10.3) |
| MSFC z-score,e mean ± SD | 0.5 (0.4) | 0.6 (0.5) |
| Timed 25-foot walk test, seconds,f mean ± SD | 4.8 (1.4) | 4.7 (1.6) |
| Nine-hole peg test, seconds,e mean ± SD | 20.1 (3.8) | 19.6 (3.3) |
| PASAT-3 second, total correct,g mean ± SD | 48.7 (10.2) | 50.2 (9.7) |
| Binocular 2.5% low-contrast letter acuity,e mean ± SD | 36 (10) | 34 (10) |
| Overall FAMS score, mean ± SD | 126 (24) | 126 (27) |
EDSS (Expanded Disability Status Scale); MSFC (Multiple Sclerosis Functional Composite); PASAT (Paced Auditory Serial Addition Test); FAMS (Functional Assessment in Multiple Sclerosis).
Study sites that enrolled at least one participant included: Johns Hopkins University (coordinating center and enrolling site), University of California, San Francisco, Swedish Medical Services, University of Rochester, University of Virginia, Oregon Health and Science University, Columbia University, University of Massachusetts in Worcester, Stanford University, Washington University at St. Louis, Anne Arundel Health System Research Institute, Cleveland Clinic, Yale University, University of Pennsylvania, Dignity Health Medical Foundation and Icahn School of Medicine at Mount Sinai.
Missing for 2 in 600 IU dose group and 3 in 5000 IU dose group.
Missing for 8 in 600 IU dose group and 8 in 5000 IU dose group.
Missing for 9 in 600 IU dose group and 7 in 5000 IU dose group.
Missing for 6 in 600 IU dose group and 7 in 5000 IU dose group.
Missing for 3 in 5000 IU dose group.
Missing for 1 in 600 IU dose group and 3 in 5000 IU dose group.
Missing for 1 in 600 IU dose group and 5 in 5000 IU dose group.