Skip to main content
NCBI home page
Journal of Medical Genetics logoLink to Journal of Medical Genetics
. 1974 Jun;11(2):177–180. doi: 10.1136/jmg.11.2.177

Frequency of deletion of short arm satellites in acrocentric chromosomes

Johannes Nielsen 1, Ursula Friedrich 1, Ástrádur B Hreidarsson 1
PMCID: PMC1013115  PMID: 4135219

Abstract

The frequency of deletion of short arm satellites has been examined in various populations. Four out of 2509 males in psychiatric institutions and prisons had Dps- or Gps- (1·6 per 1000), and five out of 6187 persons in the general population had Dps- or Gps- (0·8 per 1000). The difference is not significant.

The segregation rate of the chromosome with lack of short arm satellite material did not deviate from unity in the few families where such calculations were possible. There was no increase in abortions or non-disjunction in the families with an acrocentric chromosome lacking short arm satellite material.

The study indicates that the frequency of Dps- and Gps- in the population is between 0·5 and 1·0 per 1000 and that the lack of short arm satellite material is without any deleterious effect on phenotype.

Full text

PDF
177

Images in this article

179Image
on p.179
179Image
on p.179

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bias W. B., Migeon B. R. Haptoglobin: a locus on the D1 chromosome? Am J Hum Genet. 1967 May;19(3 Pt 2):393–398. [PMC free article] [PubMed] [Google Scholar]
  2. Brogger A. Exclusion of marker genes from the short arm of the human chromosome D1 by deletion mapping. Hereditas. 1969;62(1):116–130. [PubMed] [Google Scholar]
  3. Emerit I., Noel B., Thiriet M., Loubon M., Quack B. Short arm deletion of chromosome 14. Humangenetik. 1972;15(1):33–38. doi: 10.1007/BF00273429. [DOI] [PubMed] [Google Scholar]
  4. Hamerton J. L., Ray M., Abbott J., Williamson C., Ducasse G. C. Chromosome studies in a neonatal population. Can Med Assoc J. 1972 Apr 8;106(7):776–779. [PMC free article] [PubMed] [Google Scholar]
  5. Jagiello G., Faiman C. Unilateral fixation of the ossicular chain associated with G-group chromosome deletion. Can Med Assoc J. 1967 May 27;96(21):1405–1407. [PMC free article] [PubMed] [Google Scholar]
  6. Kelch R. P., Franklin M., Schmickel R. D. Group G deletion syndromes. J Med Genet. 1971 Sep;8(3):341–345. doi: 10.1136/jmg.8.3.341. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. MIGEON B. R. FAMILIAL VARIANT AUTOSOMES: NEW HUMAN CYTOGENETIC MARKERS. Bull Johns Hopkins Hosp. 1965 Jun;116:396–402. [PubMed] [Google Scholar]
  8. Parker C. E., Koch R., Mavalwala J., Derencsenyi A., Hatashita A. Familial deletion of the short arm of the D1-chromosome (46, XX, 13 p-) not associated with loss of haptoglobin or catalase activity. Clin Pediatr (Phila) 1969 Aug;8(8):453–458. doi: 10.1177/000992286900800808. [DOI] [PubMed] [Google Scholar]
  9. Starkman M. N., Shaw M. W. Atypical acrocentric chromosomes in Negro and Caucasian Mongols. Am J Hum Genet. 1967 Mar;19(2):162–173. [PMC free article] [PubMed] [Google Scholar]
  10. Warren R. J., Rimoin D. L. The G deletion syndromes. J Pediatr. 1970 Oct;77(4):658–663. doi: 10.1016/s0022-3476(70)80209-8. [DOI] [PubMed] [Google Scholar]
  11. Yoshida M. C., Honda T. Familial occurrence of a short arm deletion of a G-group chromosome. Jinrui Idengaku Zasshi. 1969 Sep;14(2):140–144. [PubMed] [Google Scholar]
  12. de Grouchy J., Salmon C., Salmon D., Maroteaux P. Délétion du bras court d'un chromosome 13-15, hypertélorisme et phénotype haptoglobine Hp0 dans une même famille. Ann Genet. 1966 Jun;9(2):80–85. [PubMed] [Google Scholar]

Articles from Journal of Medical Genetics are provided here courtesy of BMJ Publishing Group

RESOURCES