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. 1974 Dec;11(4):341–348. doi: 10.1136/jmg.11.4.341

Haemoglobin D Punjab (D Los Angeles)

F Vella *, H Lehmann †
PMCID: PMC1013202  PMID: 4613830

Abstract

A search for haemoglobin variants undertaken in Canada revealed 21 unrelated instances of Hb D Punjab amongst 207,300 specimens tested. Of these, eight came from East Indian immigrants and the rest from Canadians of United Kingdom origin. No instances of Hb D Punjab were found in 14,500 specimens from Canadian Indians that were tested. The geographical origins of 27 instances of Hb D Punjab characterized at the MRC Abnormal Haemoglobin Unit, Cambridge are presented. Of these five were natives of the British Isles. The results of surveys undertaken in the United Kingdom are summarized. The global distribution of Hb D Punjab is discussed.

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Selected References

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  1. ARENDS T., LAYRISSE M., RINCON A. R. Sickle cell-haemoglobin D disease in a Portuguese child. Acta Haematol. 1959 Aug;22:118–126. doi: 10.1159/000205766. [DOI] [PubMed] [Google Scholar]
  2. ATWATER J., SCHWARTZ R., TOCANTINS L. M. A variety of human hemoglobin with 4 distinct electrophoretic components. Blood. 1960 Jun;15:901–908. [PubMed] [Google Scholar]
  3. Ahern E. J., Swan A. V., Ahern V. N. The prevalence of the rarer inherited haemoglobin defects in adult Jamaicans. Br J Haematol. 1973 Oct;25(4):437–444. doi: 10.1111/j.1365-2141.1973.tb01756.x. [DOI] [PubMed] [Google Scholar]
  4. BABIN D. R., JONES R. T., SCHROEDER W. A. HEMOGLOBIN D-LOS ANGELES: ALPHA-2A BETA 2-121 GLUNH2. Biochim Biophys Acta. 1964 Apr 4;86:136–143. [PubMed] [Google Scholar]
  5. BAGLIONI C. Abnormal human haemoglobins. VII. Chemical studies on haemoglobin D. Biochim Biophys Acta. 1962 May 21;59:437–449. doi: 10.1016/0006-3002(62)90194-4. [DOI] [PubMed] [Google Scholar]
  6. BAGLIONI C., INGRAM V. M. Abnormal human haemoglobins. V. Chemical investigation of haemoglobins A, G, C, X from one individual. Biochim Biophys Acta. 1961 Apr 1;48:253–265. doi: 10.1016/0006-3002(61)90475-9. [DOI] [PubMed] [Google Scholar]
  7. BOI-DOKU F. S., LEHMANN H., BEALE D. HAEMOGLOBIN GACCA. Nature. 1964 Jul 25;203:363–365. doi: 10.1038/203363a0. [DOI] [PubMed] [Google Scholar]
  8. BOWMAN B., INGRAM V. M. Abnormal human haemoglobins. VII. The comparison of normal human haemoglobin and haemoglobin D-Chicago. Biochim Biophys Acta. 1961 Nov 11;53:569–573. doi: 10.1016/0006-3002(61)90216-5. [DOI] [PubMed] [Google Scholar]
  9. Beaven G. H. X. Haemoglobin studies of Yemenite and Kurdish Jews in Israel. Philos Trans R Soc Lond B Biol Sci. 1973 Oct 18;266(876):185–193. doi: 10.1098/rstb.1973.0046. [DOI] [PubMed] [Google Scholar]
  10. Bello A., Dorantes S., Alvarez C., De Barrios E. Z., Sedas T. Hemoglobina D Punjab en una familia mexicana, con dos casos clínicos de hemoglobinopatía S-D. Rev Invest Clin. 1969 Oct-Dec;21(4):489–496. [PubMed] [Google Scholar]
  11. Blackwell R. Q., Liu C. S. Hemoglobin G Taichung: alpha-74 Asp leads to His. Biochim Biophys Acta. 1970 Jan 20;200(1):70–75. doi: 10.1016/0005-2795(70)90044-9. [DOI] [PubMed] [Google Scholar]
  12. Blackwell R. Q., Ro I. H., Liu C. S., Yang H. J., Wang C. C., Huang J. T. Hemoglobin variant found in Koreans, Chinese, and North American Indians: alpha-2 beta-2 22 Glu Ala. Am J Phys Anthropol. 1969 May;30(3):389–391. doi: 10.1002/ajpa.1330300307. [DOI] [PubMed] [Google Scholar]
  13. Blackwell R. Q., Weng M. I., Liu C. S., Shih T. B., Wang C. L. Hemoglobin G Chinese in Chinese subjects in Taiwan. Vox Sang. 1972;23(4):363–368. doi: 10.1111/j.1423-0410.1972.tb03472.x. [DOI] [PubMed] [Google Scholar]
  14. Bloch M., Rivera H. Hemoglobinas anormales y deficiencia de glucosa-6-fosfato dehidrogenasa en El Salvador. Sangre (Barc) 1969;14(2):121–124. [PubMed] [Google Scholar]
  15. Bookchin R. M., Nagel R. L., Ranney H. M. The effect of beta 73 Asn on the interactions of sickling hemoglobins. Biochim Biophys Acta. 1970 Nov 17;221(2):373–375. doi: 10.1016/0005-2795(70)90279-5. [DOI] [PubMed] [Google Scholar]
  16. Botha M. C., van Zyl L. J. Abnormal haemoglobins in Cape Town; (occurrence and significance). S Afr Med J. 1966 Aug 27;40(32):753–756. [PubMed] [Google Scholar]
  17. Bowman B. H., Barnett D. R., Hite R. Hemoglobin G-Coushatta: a beta variant with a delta-like substitution. Biochem Biophys Res Commun. 1967 Feb 21;26(4):466–470. doi: 10.1016/0006-291x(67)90570-0. [DOI] [PubMed] [Google Scholar]
  18. Bowman B. H., Barnett D. R., Hodgkinson K. T., Schneider R. G. Chemical characterization of haemoglobin G-St-I. Nature. 1966 Sep 17;211(5055):1305–1306. doi: 10.1038/2111305a0. [DOI] [PubMed] [Google Scholar]
  19. CHERNOFF A. I. On the prevalence of hemoglobin D in the American Negro. Blood. 1956 Oct;11(10):907–909. [PubMed] [Google Scholar]
  20. CHERNOFF A. I., PETTIT N., Jr THE AMINO ACID COMPOSITION OF HEMOGLOBIN. VI. SEPARATION OF THE TRYPTIC PEPTIDES OF HEMOGLOBIN KNOXVILLE NO. I ON DOWEX-I X-2 AND SEPHADEX. Biochim Biophys Acta. 1965 Jan 4;97:47–60. doi: 10.1016/0304-4165(65)90268-0. [DOI] [PubMed] [Google Scholar]
  21. CHERNOFF A. I. The hemoglobin D syndromes. Blood. 1958 Feb;13(2):116–127. [PubMed] [Google Scholar]
  22. CHERNOFF A. I., WEICHSELBAUM T. E. A microhemolyzing technic for preparing solutions of hemoglobin for paper electrophoretic analysis. Am J Clin Pathol. 1958 Aug;30(2):120–125. doi: 10.1093/ajcp/30.2.120. [DOI] [PubMed] [Google Scholar]
  23. Cabannes R., Taleb N., Ghorra F., Schmitt-Beurrier A. Etudes des types hémoglobiniques dans la population du Liban. Nouv Rev Fr Hematol. 1965 Nov-Dec;5(6):851–856. [PubMed] [Google Scholar]
  24. Cawein M. J., Lappat E. J., Brangle R. W., Farley C. H. Hemoglobin S-D disease. Ann Intern Med. 1966 Jan;64(1):62–70. doi: 10.7326/0003-4819-64-1-62. [DOI] [PubMed] [Google Scholar]
  25. Cook I. A., Lehmann H. Beta-thalassaemia and some rare haemoglobin variants in the highlands of Scotland. Scott Med J. 1973 Jan;18(1):14–20. doi: 10.1177/003693307301800104. [DOI] [PubMed] [Google Scholar]
  26. DANCE N., HUEHNS E. R., SHOOTER E. M. THE CHEMICAL INVESTIGATION OF HAEMOGLOBINS GBRISTOL AND GBRISTO C. Biochim Biophys Acta. 1964 Apr 4;86:144–148. doi: 10.1016/0304-4165(64)90168-0. [DOI] [PubMed] [Google Scholar]
  27. DHERTE P., VANDEPITTE J., AGER J. A., LEHMANN H. Stanleyville I and II: two new variants of adult haemoglobin. Br Med J. 1959 Aug 29;2(5147):282–284. doi: 10.1136/bmj.2.5147.282. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. De Jong W. W., Went L. N. Haemoglobin J Baltimor (alpha 2 beta 2 16 gly--asp) and Haemoglobin D Punjab (alpha 2 beta 2 121 glu--gln) in two Dutch families. Acta Genet Stat Med. 1968;18(5):429–443. [PubMed] [Google Scholar]
  29. Deliyannis G. A., Ballas A., Christakis I. Haemoglobin D in a Greek family. Acta Haematol. 1969;41(2):121–125. doi: 10.1159/000208840. [DOI] [PubMed] [Google Scholar]
  30. Elion J., Belkhodja O., Wajcman H., Labie D. Two variants of hemoglobin D in the algerian population: hemoglobin D Ouled Rabah 19 (BI) Asn leads to Lys and hemoglobin D Iran 22 (Br) Glu leads to Gln. Biochim Biophys Acta. 1973 Jun 15;310(2):360–364. doi: 10.1016/0005-2795(73)90117-7. [DOI] [PubMed] [Google Scholar]
  31. FLATZ G., PIK C., SRINGAM S. HAEMOGLOBINOPATHIES IN THAILAND. II. INCIDENCE AND DISTRIBUTION OF ELEVATIONS OF HAEMOGLOBIN A2 AND HAEMOGLOBIN F; A SURVEY OF 2790 PEOPLE. Br J Haematol. 1965 Mar;11:227–236. doi: 10.1111/j.1365-2141.1965.tb06582.x. [DOI] [PubMed] [Google Scholar]
  32. GAMMACK D. B., HUEHNS E. R., LEHMANN H., SHOOTER E. M. The abnormal polypeptide chains in a number of haemoglobin variants. Acta Genet Stat Med. 1961;11:1–16. doi: 10.1159/000151139. [DOI] [PubMed] [Google Scholar]
  33. GITHENS J. H., KNOCK H. K., HATHAWAY W. E. Prevalence of abnormal hemoglobins in American Indian children. Survey in the Rocky Mountain area. J Lab Clin Med. 1961 May;57:755–758. [PubMed] [Google Scholar]
  34. GOUTTAS A., TSEVRENIS H., PAPASPYROU A., POUGOURAS P., FERTAKIS A., VORIAS [Hemoglobinosis D in Greece]. Sangre (Barc) 1960;31:303–306. [PubMed] [Google Scholar]
  35. HUNTSMAN R. G., HALL M., LEHMANN H., SUKUMARAN P. K. A second and a third abnormal haemoglobin in Norfolk. Haemoglobin G Norfolk and haemoglobin D Norfolk. Br Med J. 1963 Mar 16;1(5332):720–722. doi: 10.1136/bmj.1.5332.720. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. HYNES M., LEHMANN H. Haemoglobin D in a Persian girl: presumably the first case of haemoglobin-D-thalassaemia. Br Med J. 1956 Oct 20;2(4998):923–924. doi: 10.1136/bmj.2.4998.923. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. ITANO H. A. Solubilities of naturally occurring mixtures of human hemoglobin. Arch Biochem Biophys. 1953 Nov;47(1):148–159. doi: 10.1016/0003-9861(53)90444-5. [DOI] [PubMed] [Google Scholar]
  38. Imamura T., Riggs A. Identification of hemoglobin Oak ridge with hemoglobin D Punjab (Los Angeles). Biochem Genet. 1972 Oct;7(2):127–130. doi: 10.1007/BF00486083. [DOI] [PubMed] [Google Scholar]
  39. Itano H. A. A Third Abnormal Hemoglobin Associated with Hereditary Hemolytic Anemia. Proc Natl Acad Sci U S A. 1951 Dec;37(12):775–784. doi: 10.1073/pnas.37.12.775. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. JACOB G. F., LEHMANN H., RAPER A. B. Haemoglobin D in Indians of Gujerati origin in Uganda. East Afr Med J. 1956 Apr;33(4):135–138. [PubMed] [Google Scholar]
  41. Kohne E., König E., Roggenback H. J., Augener W., Brittinger G., Kleihauer E. Hämoglobin D-Punjap bei einmen deutschen Patienten. Verh Dtsch Ges Inn Med. 1972;78:1596–1597. [PubMed] [Google Scholar]
  42. Konotey-Ahulu F. I., Gallo E., Lehmann H., Ringelhann B. Haemoglobin Korle-Bu (beta 73 aspartic acid replaced by asparagine) showing one of the two amino acid substitutions of haemoglobin C Harlem. J Med Genet. 1968 Jun;5(2):107–111. doi: 10.1136/jmg.5.2.107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. LEHMANN H. A further example of haemoglobin D in a Turkish family. Trans R Soc Trop Med Hyg. 1956 Mar;50(2):178–180. doi: 10.1016/0035-9203(56)90080-3. [DOI] [PubMed] [Google Scholar]
  44. LEHMANN H., NWOKOLO C. The River Niger as a barrier in the spread eastwards of haemoglobin C: a survey of haemoglobins in the lbo. Nature. 1959 Jun 6;183(4675):1587–1588. doi: 10.1038/1831587a0. [DOI] [PubMed] [Google Scholar]
  45. LIDDELL J., BROWN D., BEALE D., LEHMANN H., HUNTSMAN R. G. A NEW HAEMOGLOBIN-JA OXFORD FOUND DURING A SURVEY OF AN ENGLISH POPULATION. Nature. 1964 Oct 17;204:269–270. doi: 10.1038/204269a0. [DOI] [PubMed] [Google Scholar]
  46. Lehmann H., Ala F., Hedeyat S., Montazemi K., Nejad H. K., Lightman S., Kopeć A. C., Mourant A. E., Teesdale P., Tills D. XI. The hereditary blood factors of the Kurds of Iran. Philos Trans R Soc Lond B Biol Sci. 1973 Oct 18;266(876):195–205. doi: 10.1098/rstb.1973.0047. [DOI] [PubMed] [Google Scholar]
  47. Licenziati M. Incidenza delle emoglobinopatie nella provincia di Napli. Minerva Med. 1969 Jan 17;60(5):140–141. [PubMed] [Google Scholar]
  48. Lisker R., Zarate G., Loria A. Studies on several genetic hematologic traits of Mexicans IX. Abnormal hemoglobins and erythrocytic glucose-6-phosphate dehydrogenase deficiency in several Indian tribes. Blood. 1966 Jun;27(6):824–830. [PubMed] [Google Scholar]
  49. MARDER V. J., CONLEY C. L. Electrophoresis of hemoglobin on agar gels; frequency of hemoglobin D in a Negro population. Bull Johns Hopkins Hosp. 1959 Aug;105(2):77–88. [PubMed] [Google Scholar]
  50. MARTIN H., HEUPKE G., PFLEIDERER G., WOERNER W. [Hemoglobin D in a Frankfurt family]. Folia Haematol (Frankf) 1960 Apr;4:233–241. [PubMed] [Google Scholar]
  51. MINNICH V., CORDONNIER J. K., WILLIAMS W. J., MOORE C. V. Alpha, beta and gamma hemoglobin polypeptide chains during the neonatal period with description of a fetal form of hemoglobin Da-St. Louis. Blood. 1962 Feb;19:137–167. [PubMed] [Google Scholar]
  52. MYERSON R. M., HARRISON E., LOHMULLER H. W. Incidence and significance of abnormal hemoglobins; report of a series of 1,000 hospitalized Negro veterans. Am J Med. 1959 Apr;26(4):543–546. doi: 10.1016/0002-9343(59)90277-3. [DOI] [PubMed] [Google Scholar]
  53. Marengo-Rowe A. J., McCracken A. W., Flanagan P. Complete suppression of haemoglobin A synthesis in haemoglobin D Los Angeles--beta thalassaemia. J Clin Pathol. 1968 Jul;21(4):508–510. doi: 10.1136/jcp.21.4.508. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Milner P. F. High incidence of haemoglobin G Accra in a rural district in Jamaica. J Med Genet. 1967 Jun;4(2):88–90. doi: 10.1136/jmg.4.2.88. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. Monn E., Gaffney P. J., Jr, Lehmann H. Haemoglobin Sogn (beta 14 arginine) a new haemoglobin variant. Scand J Haematol. 1968;5(5):353–360. [PubMed] [Google Scholar]
  56. Nilsson L. O., Eriksson A. W. Screening for haemoglobin and lactate dehydrogenase variants in the Icelandic, Swedish, Finnish, Lappish, Mari and Greenland Eskimo populations. Hum Hered. 1972;22(4):372–379. doi: 10.1159/000152513. [DOI] [PubMed] [Google Scholar]
  57. Ozsoylu S. Homozygous hemoglobin D Punjab. Acta Haematol. 1970;43(6):353–359. doi: 10.1159/000208751. [DOI] [PubMed] [Google Scholar]
  59. POLLITZER W. S., CHERNOFF A. I., HORTON L. L., FROEHLICH M. Hemoglobin patterns in American Indians. Science. 1959 Jan 23;129(3343):216–216. doi: 10.1126/science.129.3343.216. [DOI] [PubMed] [Google Scholar]
  60. RAPER A. B., GAMMACK D. B., HUEHNS E. R., SHOOTER E. M. Four haemoglobins in one individual. A study of the genetic interaction of Hb-G and Hb-C. Br Med J. 1960 Oct 29;2(5208):1257–1261. doi: 10.1136/bmj.2.5208.1257. [DOI] [PMC free article] [PubMed] [Google Scholar]
  61. RESTREPO A. M., LONDONO O. G. SICKLE CELL HEMOGLOBIN D DISEASE IN A NEGRO COLOMBIAN PATIENT. Ann Intern Med. 1965 Jun;62:1301–1306. doi: 10.7326/0003-4819-62-6-1301. [DOI] [PubMed] [Google Scholar]
  62. ROBINSON A. R., ROBSON M., HARRISON A. P., ZUELZER W. W. A new technique for differentiation of hemoglobin. J Lab Clin Med. 1957 Nov;50(5):745–752. [PubMed] [Google Scholar]
  63. Rahbar S., Beale D., Isaacs W. A., Lehmann H. Abnormal haemoglobins in Iran. Observation of a new variant--haemoglobin J Iran (alpha-2-beta-2 77 His--Asp). Br Med J. 1967 Mar 18;1(5541):674–677. doi: 10.1136/bmj.1.5541.674. [DOI] [PMC free article] [PubMed] [Google Scholar]
  64. Rahbar S. Haemoglobin D Iran: 2 22 glutamic acid leads to glutamine (B4). Br J Haematol. 1973 Jan;24(1):31–35. doi: 10.1111/j.1365-2141.1973.tb05724.x. [DOI] [PubMed] [Google Scholar]
  65. Ramot B., Rotem J., Rahbar S., Jacobs A. S., Uden L., Ranney H. M. Hemoglobin D Punjab in a Bulgarian Jewish family. Isr J Med Sci. 1969 Sep-Oct;5(5):1066–1070. [PubMed] [Google Scholar]
  66. Ricco G., Gallo E., Mazza U., Papa G., Inglott G. Studio su un caso di Hb D Punjab (alpha 2 beta 2 121-Glu-Gln) Boll Soc Ital Biol Sper. 1970 Apr 15;46(7):341–344. [PubMed] [Google Scholar]
  67. Rohe R. A., Sharma V., Ranney H. M. Hemoglobin D Iran alpha A2 beta 22 2-Glu leads to Gln in association with thalassemia. Blood. 1973 Sep;42(3):455–462. [PubMed] [Google Scholar]
  68. Rossi U., Morelli A. Emoglobine rare: frequenza presso la popolazione della provincia di Milano. Folia Hered Pathol (Milano) 1970 Jan;19(1):29–33. [PubMed] [Google Scholar]
  69. Rothman M. C., Ranney H. M. Double heterozygosity for hemoglobin G (alpha-2 68Lys beta-A2) and hemoglobin D (alpha A2-beta-121Gln). Blood. 1971 Feb;37(2):177–183. [PubMed] [Google Scholar]
  70. SCHNEIDER R. G., HAGGARD M. E., MCNUTT C. W., JOHNSON J. E., Jr HEMOGLOBIN G-COUSHATTA: A NEW VARIANT IN AN AMERICAN INDIAN FAMILY. Science. 1964 Feb 14;143(3607):697–698. doi: 10.1126/science.143.3607.697. [DOI] [PubMed] [Google Scholar]
  71. SINGER K., CHERNOFF A. I., SINGER L. Studies on abnormal hemoglobins. I. Their demonstration in sickle cell anemia and other hematologic disorders by means of alkali denaturation. Blood. 1951 May;6(5):413–428. [PubMed] [Google Scholar]
  72. SMITH E. W., CONLEY C. L. Sickle cellhemoglobin D disease. Ann Intern Med. 1959 Jan;50(1):94–105. doi: 10.7326/0003-4819-50-1-94. [DOI] [PubMed] [Google Scholar]
  73. STEWART J. W., MACIVER J. E. Sickle-cell/haemoglobin-D disease in a mulatto girl. Lancet. 1956 Jan 7;270(6906):23–25. doi: 10.1016/s0140-6736(56)91858-x. [DOI] [PubMed] [Google Scholar]
  74. STOUT C., HOLLAND C. K., BIRD R. M. HEMOGLOBIN D IN AN OKLAHOMA FAMILY. Arch Intern Med. 1964 Aug;114:296–300. doi: 10.1001/archinte.1964.03860080146016. [DOI] [PubMed] [Google Scholar]
  75. STURGEON P., ITANO H. A., BERGREN W. R. Clinical manifestations of inherited abnormal hemoglobins. I. The interaction of hemoglobin-S with hemoglobin-D. Blood. 1955 May;10(5):389–404. [PubMed] [Google Scholar]
  76. Sadikario A., Duma H., Efremov G., Mladenovski B., Andreeva M., Petkov G., Lazova C. Thalassaemias and abnormal haemoglobins in SR macedonia. A survey of 2,861 children. Acta Haematol. 1969;41(3):162–169. doi: 10.1159/000208846. [DOI] [PubMed] [Google Scholar]
  77. Salzano F. M., Tondo C. V. Hemoglobin types of Brazilian Indians. Am J Phys Anthropol. 1968 May;28(3):355–359. doi: 10.1002/ajpa.1330280323. [DOI] [PubMed] [Google Scholar]
  78. Schneider R. G., Ueda S., Alperin J. B., Levin W. C., Jones R. T., Brimhall B. Hemoglobin D Los Angeles in two Caucasian families: hemoglobin SD disease and hemoglobin D thalassemia. Blood. 1968 Aug;32(2):250–259. [PubMed] [Google Scholar]
  79. Sick K., Beale D., Irvine D., Lehmann H., Goodall P. T., MacDougall S. Haemoglobin G Copenhagen and haemoglobin J Cambridge. Two new beta-chain variants of haemoglobin A. Biochim Biophys Acta. 1967 Jun 27;140(2):231–242. doi: 10.1016/0005-2795(67)90463-1. [DOI] [PubMed] [Google Scholar]
  80. Stern M. A., Kynoch P. A., Lehmann H. Beta-thalassaemia, glucose-6-phosphate-dehydrogenase deficiency, and haemoglobin D-Punjab in Pathans. Lancet. 1968 Jun 15;1(7555):1284–1285. doi: 10.1016/s0140-6736(68)92296-4. [DOI] [PubMed] [Google Scholar]
  81. Stuart J., Schwartz F. C., Little A. J., Raine D. N. Screening for abnormal haemoglobins: a pilot study. Br Med J. 1973 Nov 3;4(5887):284–287. doi: 10.1136/bmj.4.5887.284. [DOI] [PMC free article] [PubMed] [Google Scholar]
  82. Ungar B., Symons H. S., Anderson G. R., Stubbs A. E., Wiltshire B. G., Lehmann H. Haemoglobin D Punjab in a European family in Australia. Med J Aust. 1973 Feb 17;1(7):354–356. doi: 10.5694/j.1326-5377.1973.tb200052.x. [DOI] [PubMed] [Google Scholar]
  83. Uriarte A., Perez Atencio R., Colombo B. Haemoglobin D Punjab in a Cuban family and its interaction with haemoglobin S. Acta Haematol. 1973;50(5):315–320. doi: 10.1159/000208365. [DOI] [PubMed] [Google Scholar]
  84. VENTRUTO V., COLOMBO B., CANIGLIA A., DEROSA L. STUDIO DI TRE FAMIGLIE CON EMOGLOBINOSI D. Haematologica. 1963;48:873–884. [PubMed] [Google Scholar]
  85. Vella F., Isaacs W. A., Lehmann H. Hemoglobin G Saskatoon: beta-22Glu--Ala. Can J Biochem. 1967 Feb;45(2):351–353. doi: 10.1139/o67-041. [DOI] [PubMed] [Google Scholar]
  86. Vella F., Lorkin P. A., Carrell R. W., Lehmann H. A new hemoglobin variant resembling hemoglobin E. Hemoglobin E Saskatoon: beta-22 Glu replaced by Lys. Can J Biochem. 1967 Sep;45(9):1385–1391. doi: 10.1139/o67-163. [DOI] [PubMed] [Google Scholar]
  87. WATSON-WILLIAMS E. J., BEALE D., IRVINE D., LEHMANN H. A NEW HAEMOGLOBIN, D IBADAN (BETA-87 THREONINE -- LYSINE), PRODUCING NO SICKLE-CELL HAEMOGLOBIN D DISEASE WITH HAEMOGLOBIN S. Nature. 1965 Mar 27;205:1273–1276. doi: 10.1038/2051273a0. [DOI] [PubMed] [Google Scholar]
  88. WEATHER ALL D. J., SIGLER A. T., BAGLIONI C. Four hemoglobins in each of three brothers. Genetic and biochemical significance. Bull Johns Hopkins Hosp. 1962 Sep;111:143–156. [PubMed] [Google Scholar]
  89. WHITE J. C., BEAVER G. H. A review of the varieties of human haemoglobin in health and disease. J Clin Pathol. 1954 Aug;7(3):175–200. doi: 10.1136/jcp.7.3.175. [DOI] [PMC free article] [PubMed] [Google Scholar]
  90. Wade P. T., Jenkins T., Huehns E. R. Haemoglobin variant in a Bushman: haemoglobin D-beta-Bushman-alpha-beta-22-16-gly-arg. Nature. 1967 Nov 18;216(5116):688–690. doi: 10.1038/216688b0. [DOI] [PubMed] [Google Scholar]
  91. Wajcman H., Boigne J. M., Labie D., Seringe P. Hemoglobine D Los Angeles. Mise en evidence de l'anomalie de structure par une amelioration des methodes. Biochim Biophys Acta. 1969 Aug 12;188(1):55–58. [PubMed] [Google Scholar]
  92. Wasi P., Pootrakul S., Na-Nakorn S., Beale D., Lehmann H. Haemoglobin D-beta Los Angeles (D Punjab, alpha-2-beta-2 121 Glu NH2) in a Thai family. Acta Haematol. 1968;39(3):151–158. doi: 10.1159/000208955. [DOI] [PubMed] [Google Scholar]

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