Skip to main content
Journal of Medical Genetics logoLink to Journal of Medical Genetics
. 1974 Dec;11(4):349–352. doi: 10.1136/jmg.11.4.349

Haptoglobins in chronic lymphatic leukaemia

S S Papiha 1,2, A L Jones 1,2, B Thompson 1,2, D Carr 1,2
PMCID: PMC1013204  PMID: 4443984

Abstract

Haptoglobin phenotypes have been determined in 30 chronic lymphatic leukaemia patients and concentrations determined in 21 of these. The number of Hp1 phenotypes is slightly raised but not significantly so compared with a control population and is the same as that in first-degree relatives. Haptoglobin concentrations show higher concentrations in Hp1 than Hp2, as has previously been reported. It is concluded that haptoglobin genes contribute very little to any genetic influence on lymphatic leukaemia.

Full text

PDF
349

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALLISON A. C. The genetical and clinical significance of the haptoglobins. Proc R Soc Med. 1958 Aug;51(8):641–645. [PubMed] [Google Scholar]
  2. BAYANI-SIOSON P. S., LOUCH J., SUTTON H. E., NEEL J. V., HORNE S. L., GERSHOWITZ H. Quantitative studies on the haptoglobin of apparently healthy adult male twins. Am J Hum Genet. 1962 Jun;14:210–219. [PMC free article] [PubMed] [Google Scholar]
  3. LATNER A. L., ZAKI A. H. Clinical uses of starch gel electrophoresis with special reference to leukaemia. Clin Chim Acta. 1960 Jan;5:22–25. doi: 10.1016/0009-8981(60)90084-x. [DOI] [PubMed] [Google Scholar]
  4. MILLER R. W. RADIATION, CHROMOSOMES AND VIRUSES IN THE ETIOLOGY OF LEUKEMIA. EVIDENCE FROM EPIDEMIOLOGIC RESEARCH. N Engl J Med. 1964 Jul 2;271:30–36. doi: 10.1056/NEJM196407022710106. [DOI] [PubMed] [Google Scholar]
  5. NYMAN M. Uber Haptoglobinbestimmung im Serum, Normalkonzentration und Verhältnis zu Smithies Serumgruppen. Clin Chim Acta. 1958 Jan;3(1):111–113. doi: 10.1016/0009-8981(58)90067-6. [DOI] [PubMed] [Google Scholar]
  6. OWEN J. A., BETTER F. C., HOBAN J. A simple method for the determination of serum haptoglobins. J Clin Pathol. 1960 Mar;13:163–164. doi: 10.1136/jcp.13.2.163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. POULIK M. D. Starch gel electrophoresis in a discontinous system of buffers. Nature. 1957 Dec 28;180(4600):1477–1479. doi: 10.1038/1801477a0. [DOI] [PubMed] [Google Scholar]
  8. Peacock A. C. Serum haptoglobin type and leukemia: an association with possible etiological significance. J Natl Cancer Inst. 1966 Apr;36(4):631–639. doi: 10.1093/jnci/36.4.631. [DOI] [PubMed] [Google Scholar]
  9. SMITHIES O., WALKER N. F. Notation for serum-protein groups and the genes controlling their inheritance. Nature. 1956 Sep 29;178(4535):694–695. doi: 10.1038/178694a0. [DOI] [PubMed] [Google Scholar]
  10. Smith H., Owen J. A. The determination of haptoglobins in normal human serum. Biochem J. 1961 Apr;78(4):723–728. doi: 10.1042/bj0780723. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Sutton H. E. The haptoglobins. Prog Med Genet. 1970;7:163–216. [PubMed] [Google Scholar]

Articles from Journal of Medical Genetics are provided here courtesy of BMJ Publishing Group

RESOURCES