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Journal of Medical Genetics logoLink to Journal of Medical Genetics
. 1976 Dec;13(6):462–465. doi: 10.1136/jmg.13.6.462

Age of onset in Huntington's disease: lack of parental age effect.

W Burke
PMCID: PMC1013471  PMID: 138741

Abstract

In a recent publication Brackenridge and Teltscher (1975) concluded that the age of onset of Huntington's disease was in part a function of the age of the transmitting parent at the time of birth of a subsequently affected child. Their analysis suggested that the younger the parent was at the time of birth of the subsequently affected child, the later in life symptoms of disease would appear in the child. The data of Brackenridge and Teltscher have been statistically reevaluated here, and this analysis fails to support their conclusion. Consequently it would be irresponsible to counsel persons at risk for Huntington's disease to plan families early in life.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brackenridge C. J., Teltscher B. Estimation of the age at onset of Huntington's disease from factors associated with the affected parent. J Med Genet. 1975 Mar;12(1):64–69. doi: 10.1136/jmg.12.1.64. [DOI] [PMC free article] [PubMed] [Google Scholar]
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