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. 1977 Feb;14(1):66–68. doi: 10.1136/jmg.14.1.66

Stable dicentric autosome, tdic (8:22)(p23:p13), in a mentally retarded girl.

S H Roberts, R T Howell, K M Laurence, M E Heathcote
PMCID: PMC1013511  PMID: 839505

Abstract

A dicentric autosome, tdic(8:22)(p23:p13), was found in all metaphase cells examined from the peripheral blood of a mentally retarded girl. It is suggested that the centromere of chromosome 22 was inactive, allowing the dicentric to behave as a monocentric element. The involvement of acrocentric chromosomes in the stable dicentric autosomes of man is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cohen M. M., MacGillivray M. H., Capraro V. J., Aceto T. A. Human dicentric Y chromosomes. Case report and review of the literature. J Med Genet. 1973 Mar;10(1):74–79. doi: 10.1136/jmg.10.1.74. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. De la Chapelle A., Stenstrand K. Dicentric human X chromosomes. Hereditas. 1974;76(2):259–268. doi: 10.1111/j.1601-5223.1974.tb01344.x. [DOI] [PubMed] [Google Scholar]
  3. Distèche C., Hagemeijer A., Frederic J., Progneaux D. An abnormal large human chromosome identified as an end-to-end fusion of two X's by combined results of the new banding techniques and microdensitometry. Clin Genet. 1972;3(5):388–395. doi: 10.1111/j.1399-0004.1972.tb01472.x. [DOI] [PubMed] [Google Scholar]
  4. Howell R. T., Roberts S. H., Beard R. J. Dicentric X isochromosomes in man. J Med Genet. 1976 Dec;13(6):496–500. doi: 10.1136/jmg.13.6.496. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Niebuhr E. A 45,XX,5-,13-,dic+ karyotype in a case of cri-du-chat syndrome. Cytogenetics. 1972;11(3):165–177. doi: 10.1159/000130186. [DOI] [PubMed] [Google Scholar]
  6. Niebuhr E. Dicentric and monocentric Robertsonian translocations in man. Humangenetik. 1972;16(3):217–226. doi: 10.1007/BF00273467. [DOI] [PubMed] [Google Scholar]
  7. Nielsen J., Friedrich U., Hreidarsson A. B. Frequency of deletion of short arm satellites in acrocentric chromosomes. J Med Genet. 1974 Jun;11(2):177–180. doi: 10.1136/jmg.11.2.177. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Seabright M. A rapid banding technique for human chromosomes. Lancet. 1971 Oct 30;2(7731):971–972. doi: 10.1016/s0140-6736(71)90287-x. [DOI] [PubMed] [Google Scholar]
  9. Sears E R, Câmara A. A Transmissible Dicentric Chromosome. Genetics. 1952 Mar;37(2):125–135. doi: 10.1093/genetics/37.2.125. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Subrt I., Blehová B., Táborský O. Dicentric chromosome due to an unusual fusion. Humangenetik. 1971;12(2):136–141. doi: 10.1007/BF00291469. [DOI] [PubMed] [Google Scholar]
  11. Sumner A. T., Evans H. J., Buckland R. A. New technique for distinguishing between human chromosomes. Nat New Biol. 1971 Jul 7;232(27):31–32. doi: 10.1038/newbio232031a0. [DOI] [PubMed] [Google Scholar]
  12. Therman E., Sarto G. E., Patau K. Apparently isodicentric but functionally monocentric X chromosome in man. Am J Hum Genet. 1974 Jan;26(1):83–92. [PMC free article] [PubMed] [Google Scholar]
  13. Warburton D., Henderson A. S., Shapiro L. R., Hsu L. Y. A stable human dicentric chromosome, t dic (12;14)(p13;p13) including an intercalary satellite region between centromeres. Am J Hum Genet. 1973 Jul;25(4):439–445. [PMC free article] [PubMed] [Google Scholar]
  14. Yanagisawa S., Yokoyama H. Symptoms of Turner's syndrome and interstitial heterochromatin in i(Xq). Clin Genet. 1975 Apr;7(4):299–303. doi: 10.1111/j.1399-0004.1975.tb00332.x. [DOI] [PubMed] [Google Scholar]

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