Abstract
We present a pair of dizygotic twins with different abnormal karyotypes. The chromosome anomaly is a sexual aneuploidy in both cases: 48,XXXXY in one, 47,XXY in the second. The origin of the chromosomal anomaly and the hypothetical relation between sexual aneuploidy and twinning is discussed. It is concluded that further studies in twins are necessary to prove the not yet solved problems of non-disjunction and double ovulation.
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- FERGUSON-SMITH M. A. Chromation-positive Klinefelter's syndrome (primary microrchidism) in a mental-deficiency hospital. Lancet. 1958 May 3;1(7027):928–931. doi: 10.1016/s0140-6736(58)91684-2. [DOI] [PubMed] [Google Scholar]
- HOEFNAGEL D., BENIRSCHKE K. Twinning in Klinefelter's syndrome. Lancet. 1962 Dec 15;2(7268):1282–1282. doi: 10.1016/s0140-6736(62)92863-5. [DOI] [PubMed] [Google Scholar]
- Nielsen J. Twins in sibships with Klinefelter's syndrome and the XYY syndrome. Acta Genet Med Gemellol (Roma) 1970 Jul;19(3):399–404. doi: 10.1017/s1120962300014761. [DOI] [PubMed] [Google Scholar]
- Nielsen J. Twins in sibships with Klinefelter's syndrome. J Med Genet. 1966 Jun;3(2):114–116. doi: 10.1136/jmg.3.2.114. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Penrose L. S. Finger-print pattern and the sex chromosomes. Lancet. 1967 Feb 11;1(7485):298–300. doi: 10.1016/s0140-6736(67)91237-8. [DOI] [PubMed] [Google Scholar]
- Race R. R., Sanger R. Xg and sex-chromosome abnormalities. Br Med Bull. 1969 Jan;25(1):99–103. doi: 10.1093/oxfordjournals.bmb.a070677. [DOI] [PubMed] [Google Scholar]
- Soltan H. C. Genetic characteristics of families of XO and XXY patients, including evidence of source of X chromosomes in 7 aneuploid patients. J Med Genet. 1968 Sep;5(3):173–180. doi: 10.1136/jmg.5.3.173. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tumba A. L'influence de l'age parental sur la production de l'anomalie XXXXY. J Genet Hum. 1974 Mar;22(1):73–97. [PubMed] [Google Scholar]