Table 2.
Immune cell subpopulations in all patients, patients with type 2 CRS, and CKD patients. Statistically significant differences between subgroups are highlighted in bold.
| All Patients (N = 63) |
CRS Patients (N = 39) |
CKD Patients (N = 24) |
p-Value * | |
|---|---|---|---|---|
| WBC (N) | 7730 (IQR 6224–9495) | 8360 (IQR 6730–9940) | 7330 (IQR 6070–8830) | 0.15 |
| Monocytes (N) | 500 (IQR 400–650) | 600 (IQR 400–700) | 500 (IQR 400–600) | 0.06 |
| Monocytes (%) | 6.5 (5.4–7.9) | 6.5 (IQR 5.4–8.1) | 6.6 (IQR 5.3–7.8) | 0.64 |
| CD14++CD16- (N) | 427 ± 167 | 450 ± 184 | 391 ± 132 | 0.14 |
| CD14++CD16- (%) | 81.4 ± 8.9 | 80.6 ± 10 | 82.6 ± 6.9 | 0.35 |
| CD14++CD16+ (N) | 38 (IQR 22–62) | 41 (IQR 24–78) | 35 (IQR 18–43) | 0.04 |
| CD14++CD16+ (%) | 7.4 (IQR 5.4–11.2) | 8 (IQR 5.6–12.0) | 7.3 (IQR 4.7–9.6) | 0.30 |
| CD14+CD16++ (N) | 25 (IQR 14–35) | 22 (IQR 12–36) | 25 (IQR 19–32) | 0.80 |
| CD14+CD16++ (%) | 4.6 (IQR 3.0–6.7) | 4.2 (IQR 2.7–6.6) | 5.1 (IQR 4.0–6.7) | 0.14 |
| Lymphocytes (N) | 1699 ± 658 | 1557 ± 691 | 1920 ± 545 | 0.03 |
| Lymphocytes (%) | 21.3 ± 8.7 | 18.7 ± 8.3 | 25.3 ± 8.0 | 0.002 |
| T-lymphocytes (N) | 1320 ± 500 | 1227 ± 510 | 1465 ± 455 | 0.06 |
| T-lymphocytes (%) | 79.6 ± 9.7 | 81.7 ± 8.7 | 76.3 ± 10.3 | 0.03 |
| B-lymphocytes (N) | 75 (IQR 37–140) | 68 (IQR 31–104) | 87 (IQR 58–163) | 0.08 |
| B-lymphocytes (%) | 4.7 (2.9–8.3) | 4.2 (IQR 2.2–9.0) | 5.1 (IQR 3.4–7.9) | 0.57 |
| NK cells (N) | 182 (124–328) | 148 (IQR 103–258) | 324 (IQR 179–368) | 0.001 |
| NK cells (%) | 1.7 (IQR 8.2–18.3) | 10.7 (IQR 7.1–16.6) | 16.5 (IQR 11.2–19.6) | 0.01 |
| CD4+ T-Cells (N) | 787 ± 312 | 732 ± 308 | 873 ± 304 | 0.08 |
| CD4+ T-cells (%) | 47.5 ± 10.6 | 48.6 ± 10.4 | 45.7 ± 10.9 | 0.30 |
| CD8+ T-cells (N) | 508 (IQR 353–750) | 411 (IQR 224–720) | 585 (IQR 447–786) | 0.14 |
| CD8+ T-cells (%) | 29.9 (IQR 23.5–37.9) | 28.5 (IQR 23.3–38.0) | 31.5 (IQR 24.4–36.8) | 0.73 |
| Tregs (%) | 2.4 (IQR 1.7–3.3) | 2.7 (IQR 2.0–3.9) | 2.0 (IQR 1.6–2.6) | 0.03 |
| T Regs (N) | 37 (IQR 25–51) | 36 (IQR 24–49) | 40 (IQR 26–61) | 0.94 |
Values are expressed in mean (± SD) or median (IQR 25–75th percentiles). CD, cluster of differentiation; NK, natural killer; N, number; Tregs, T regulatory cells. * p values refer to t-test significance for normal distribution variables, Mann–Whitney test significance for nonparametric variables, or chi-square test significance for categorical variables.