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. 2023 Apr 3;11(4):1082. doi: 10.3390/biomedicines11041082

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Overview of the study. Tumor tissue and whole blood were collected from pediatric patients diagnosed with cancer. Tumor tissue DNA was extracted and underwent either bisulfite conversion followed by hybridization in the EPIC BeadChip Methylation Arrays or SALSA MLPA assay. CNAs were obtained from either EPIC or MLPA data. Tumors with 1q gain, MYCN gain or TP53 gain/loss were selected for dPCR. Plasma was used for cfDNA extraction and for CNAs’ evaluation. WT, Wilms tumor; NB, neuroblastoma; ES, Ewing sarcoma; RMS, rhabdomyosarcoma; LMS, leiomyosarcoma; OS, osteosarcoma; and BT, benign teratoma.