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. 1978 Dec;15(6):424–427. doi: 10.1136/jmg.15.6.424

Genetics of adolescent idiopathic scoliosis.

A Czeizel, A Bellyei, O Barta, T Magda, L Molnár
PMCID: PMC1013756  PMID: 745214

Abstract

A genetic family study was undertaken by photofluorography of the first, second, and third degree relatives of 116 index patients with adolescent idiopathic scoliosis (AIS). The index patients were ascertained in the course of an epidemiological screening. The pattern of familial clusters and the recurrence risk related to the number of affected relatives and to the severity of the disorder in the index patients support the theory of polygenic inheritance, a multifactorial-threshold aetiological model. The recurrence risk table for first degree relative, prepared by computerised data processing and analysis, may contribute to the early diagnosis and prevention of the disorder.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beals R. K. Nosologic and genetic aspects of scoliosis. Clin Orthop Relat Res. 1973 Jun;(93):23–32. doi: 10.1097/00003086-197306000-00004. [DOI] [PubMed] [Google Scholar]
  2. Bellyei A., Czeizel A., Barta O., Magda T., Molnár L. Prevalence of adolescent idiopathic scoliosis in Hungary. Acta Orthop Scand. 1977;48(2):177–180. doi: 10.3109/17453677708985131. [DOI] [PubMed] [Google Scholar]
  3. Carter C. O. Genetics of common single malformations. Br Med Bull. 1976 Jan;32(1):21–26. doi: 10.1093/oxfordjournals.bmb.a071318. [DOI] [PubMed] [Google Scholar]
  4. Cowell H. R., Hall J. N., MacEwen G. D. Genetic aspects of idiopathic scoliosis. A Nicholas Andry Award essay, 1970. Clin Orthop Relat Res. 1972 Jul-Aug;86:121–131. doi: 10.1097/00003086-197207000-00018. [DOI] [PubMed] [Google Scholar]
  5. Czeizel A., Bodnár L., Illei G., Molnár A. The occurrence of consanguineous marriages in Hungary. Hum Hered. 1976;26(2):110–112. doi: 10.1159/000152790. [DOI] [PubMed] [Google Scholar]
  6. Czeizel A., Tusnady G. A family study on cleft lip with or without cleft palate and posterior cleft palate in Hungary. Hum Hered. 1972;22(5):405–416. doi: 10.1159/000152518. [DOI] [PubMed] [Google Scholar]
  7. De George F. V., Fisher R. L. Idiopathic scoliosis: genetic and environmental aspects. J Med Genet. 1967 Dec;4(4):251–257. doi: 10.1136/jmg.4.4.251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. GILLY R., STAGNARA P., FREDERICH A., DALLOZ C., ROBERT J. M., GOLDBLATT B. [Medical aspects of essential structural scoliosis in children]. Lyon Med. 1963 Jan 13;95:79–95. [PubMed] [Google Scholar]
  9. MacEwen G. D. The familial incidence of idiopathic scoliosis, its implication in patient care. Isr J Med Sci. 1973 Jun;9(6):711–713. [PubMed] [Google Scholar]
  10. Neugebauer H. Cobb oder Ferguson? Eine Analyse der beiden gebräuchlichsten Röntgenmessmethoden von Skoliosen. Z Orthop Ihre Grenzgeb. 1972 Jun;110(3):342–356. [PubMed] [Google Scholar]
  11. PONSETI I. V., FRIEDMAN B. Prognosis in idiopathic scoliosis. J Bone Joint Surg Am. 1950 Apr;32A(2):381–395. [PubMed] [Google Scholar]
  12. Riseborough E. J., Wynne-Davies R. A genetic survey of idiopathic scoliosis in Boston, Massachusetts. J Bone Joint Surg Am. 1973 Jul;55(5):974–982. [PubMed] [Google Scholar]
  13. Scheier H. J. Uberblick über die verschiedenen Skolioseformen nach ätiologischen Gesichtspunkten mit prognostischen Hinweisen. Z Orthop Ihre Grenzgeb. 1975 Aug;113(4):558–560. [PubMed] [Google Scholar]
  14. Smith C. Computer programme to estimate recurrence risks for multifactorial familial disease. Br Med J. 1972 Feb 19;1(5798):495–497. doi: 10.1136/bmj.1.5798.495. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Wynne-Davies R. Familial (idiopathic) scoliosis. A family survey. J Bone Joint Surg Br. 1968 Feb;50(1):24–30. [PubMed] [Google Scholar]

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