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. 1990 Jan;53(1):33–38. doi: 10.1136/jnnp.53.1.33

Measurements of regional cerebral blood flow and cognitive performance in Alzheimer's disease.

D Montaldi 1, D N Brooks 1, J H McColl 1, D Wyper 1, J Patterson 1, E Barron 1, J McCulloch 1
PMCID: PMC1014094  PMID: 2303829

Abstract

Single photon emission computed tomography (SPECT) with 99mTc-HMPAO was used to image 26 patients with dementia of the Alzheimer type (DAT) and 10 healthy controls. Regional cerebral blood flow (rCBF) data indicated a relative sparing of the occipital regions in DAT. Normalisation to occipital flow illustrated highly significant CBF deficits in a number of cortical regions, particularly in the left and right posterior--temporal cortex in DAT compared to controls. The cognitive performance of DAT patients was measured using a clinical cognitive assessment procedure (CAMCOG) and numerous correlations between these scores and rCBF were obtained. The implications and value of this investigative technique are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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