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Antiviral activity of the NBCoV small molecules in a single-cycle assay in two cell lines against pseudovirus NL4-3ΔEnv-NanoLuc/SARS-CoV-1 (IC50) and SI.
| SARS-CoV-1 | ||||
|---|---|---|---|---|
| Compound | 293T/ACE2 Cells | A549/ACE2/TMPRSS2 Cells | ||
| IC50 (nM) * | SI | IC50 (nM) * | SI | |
| NBCoV35 | 380 ± 69 | 132 | 363 ± 11 | 138 |
| NBCoV36 | 660 ± 30 | 65 | 147 ± 19 | 340 |
| NBCoV37 | 340 ± 34 | 125 | 95 ± 1 | 526 |
| NBCoV63 | 110 ± 0.5 | 455 | 59 ± 1.5 | 848 |
* The reported IC50 values represent the means ± standard deviations (n = 3).
