. 2023 Apr 19;15(4):1001. doi: 10.3390/v15041001

Table 5.

Antiviral activity of the NBCoV small molecules in the single-cycle assay in Calu-3 cells against pseudovirus SARS-CoV-2 (USA-WA1/2020) and its VOC Omicron (BA.4/BA.5), SARS-CoV-1, and MERS-CoV, toxicity, and SI.

Compounds	Calu-3 Cells
	SARS-CoV-2				SARS-CoV-1		MERS-CoV		Toxicity
	USA-WA1/2020		Omicron BA.4/BA.5		SARS-CoV-1		MERS-CoV		Toxicity
	IC₅₀ (nM) ^a	SI	IC₅₀ (nM) ^a	SI	IC₅₀ (nM) ^a	SI	IC₅₀ (nM) ^a	SI	CC₅₀ (µM) ^a
NBCoV35	360 ± 35	>139	520 ± 27	>96	1247 ± 45	>40	1667 ± 225	>30	>50
NBCoV36	433 ± 49	>116	565 ± 79	>89	627 ± 58	>80	589 ± 117	>85	>50
NBCoV37	368 ± 45	>136	583 ± 35	>86	1000 ± 132	>50	877 ± 50	>57	>50
NBCoV63	120 ± 6	417	126 ± 5	397	133 ± 28	376	220 ± 30	227	50

^a The reported values represent the means ± standard deviations (n = 3).