Table 7.
Antiviral activity of NBCoV63 against authentic viruses 1 in Calu-3 cells.
| Virus | IC50 (µM) 2 | CC50 (µM) 3 | |
|---|---|---|---|
| NBCoV63 | Remdesivir (Control) | ||
| SARS-CoV-2 Hong Kong | 2.04 | 3.44 | >50 |
| SARS-CoV-2 Delta (B.1.617.2) | 9.27 | 12.5 | |
| SARS-CoV-2 Omicron (BA.2.12.1) | 5.45 | 2.82 | |
| SARS-CoV-1 Urbani | 3.98 | 1.08 | |
| MERS-CoV | 8.01 | 17.8 | |
1 The assay was performed by SRI International, Menlo Park, CA. 2 The reported values represent the means (n = 2) and the assay was repeated. 3 CC50 of both NBCoV63 and Remdesivir in Calu-3 cells was >50 µM.