Skip to main content
PMC home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1990 Apr;53(4):327–330. doi: 10.1136/jnnp.53.4.327

Cyclosporin A in the treatment of chronic demyelinating polyradiculoneuropathy.

S J Hodgkinson 1, J D Pollard 1, J G McLeod 1
PMCID: PMC1014171  PMID: 2341846

Abstract

Eight patients with chronic inflammatory demyelinating polyneuropathy, five of whom had an associated paraproteinaemia, were treated with cyclosporin in a pilot, uncontrolled study for periods up to three and a half years after failing to respond adequately to corticosteroid and azathioprine therapy and plasmapheresis. Three patients had an excellent response, two with complete remission. In other cases it was possible to reduce the corticosteroid therapy and frequency of plasmapheresis. There were no serious complications of the treatment.

Full text

PDF
327

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bishop G. A., Hall B. M. Effects of immunosuppressive drugs on functions of activated T lymphocytes. Cyclosporine inhibition of gamma interferon production in the presence of interleukin. Transplantation. 1988 May;45(5):967–972. doi: 10.1097/00007890-198805000-00026. [DOI] [PubMed] [Google Scholar]
  2. Dyck P. J., Daube J., O'Brien P., Pineda A., Low P. A., Windebank A. J., Swanson C. Plasma exchange in chronic inflammatory demyelinating polyradiculoneuropathy. N Engl J Med. 1986 Feb 20;314(8):461–465. doi: 10.1056/NEJM198602203140801. [DOI] [PubMed] [Google Scholar]
  3. Dyck P. J., Lais A. C., Ohta M., Bastron J. A., Okazaki H., Groover R. V. Chronic inflammatory polyradiculoneuropathy. Mayo Clin Proc. 1975 Nov;50(11):621–637. [PubMed] [Google Scholar]
  4. Dyck P. J., O'Brien P., Swanson C., Low P., Daube J. Combined azathioprine and prednisone in chronic inflammatory-demyelinating polyneuropathy. Neurology. 1985 Aug;35(8):1173–1176. doi: 10.1212/wnl.35.8.1173. [DOI] [PubMed] [Google Scholar]
  5. Gross M. L., Thomas P. K. The treatment of chronic relapsing and chronic progressive idiopathic inflammatory polyneuropathy by plasma exchange. J Neurol Sci. 1981 Oct;52(1):69–78. doi: 10.1016/0022-510x(81)90135-0. [DOI] [PubMed] [Google Scholar]
  6. Kahan B. D. Cyclosporine: the agent and its actions. Transplant Proc. 1985 Aug;17(4 Suppl 1):5–18. [PubMed] [Google Scholar]
  7. King R. H., Craggs R. I., Gross M. L., Tompkins C., Thomas P. K. Suppression of experimental allergic neuritis by Cyclosporin-A. Acta Neuropathol. 1983;59(4):262–268. doi: 10.1007/BF00691491. [DOI] [PubMed] [Google Scholar]
  8. Kolkin S., Nahman N. S., Jr, Mendell J. R. Chronic nephrotoxicity complicating cyclosporine treatment of chronic inflammatory demyelinating polyradiculoneuropathy. Neurology. 1987 Jan;37(1):147–149. doi: 10.1212/wnl.37.1.147. [DOI] [PubMed] [Google Scholar]
  9. McCombe P. A., Pollard J. D., McLeod J. G. Chronic inflammatory demyelinating polyradiculoneuropathy. A clinical and electrophysiological study of 92 cases. Brain. 1987 Dec;110(Pt 6):1617–1630. doi: 10.1093/brain/110.6.1617. [DOI] [PubMed] [Google Scholar]
  10. Myers B. D., Sibley R., Newton L., Tomlanovich S. J., Boshkos C., Stinson E., Luetscher J. A., Whitney D. J., Krasny D., Coplon N. S. The long-term course of cyclosporine-associated chronic nephropathy. Kidney Int. 1988 Feb;33(2):590–600. doi: 10.1038/ki.1988.38. [DOI] [PubMed] [Google Scholar]
  11. Nathan C. F., Murray H. W., Wiebe M. E., Rubin B. Y. Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. J Exp Med. 1983 Sep 1;158(3):670–689. doi: 10.1084/jem.158.3.670. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Palestine A. G., Austin H. A., 3rd, Balow J. E., Antonovych T. T., Sabnis S. G., Preuss H. G., Nussenblatt R. B. Renal histopathologic alterations in patients treated with cyclosporine for uveitis. N Engl J Med. 1986 May 15;314(20):1293–1298. doi: 10.1056/NEJM198605153142005. [DOI] [PubMed] [Google Scholar]
  13. Pollard J. D., McCombe P. A., Baverstock J., Gatenby P. A., McLeod J. G. Class II antigen expression and T lymphocyte subsets in chronic inflammatory demyelinating polyneuropathy. J Neuroimmunol. 1986 Dec;13(2):123–134. doi: 10.1016/0165-5728(86)90059-7. [DOI] [PubMed] [Google Scholar]
  14. Pollard J. D., McLeod J. G., Gatenby P., Kronenberg H. Prediction of response to plasma exchange in chronic relapsing polyneuropathy. A clinico-pathological correlation. J Neurol Sci. 1983 Feb;58(2):269–287. doi: 10.1016/0022-510x(83)90222-8. [DOI] [PubMed] [Google Scholar]
  15. Prineas J. W. Demyelination and remyelination in recurrent idiopathic polyneuropathy. An electron microscope study. Acta Neuropathol. 1971;18(1):34–57. doi: 10.1007/BF00684474. [DOI] [PubMed] [Google Scholar]
  16. Prineas J. W., McLeod J. G. Chronic relapsing polyneuritis. J Neurol Sci. 1976 Apr;27(4):427–458. doi: 10.1016/0022-510x(76)90213-6. [DOI] [PubMed] [Google Scholar]
  17. Rosenberg N. L., Lacy J. R., Kennaugh R. C., Holers V. M., Neville H. E., Kotzin B. L. Treatment of refractory chronic demyelinating polyneuropathy with lymphoid irradiation. Muscle Nerve. 1985 Mar-Apr;8(3):223–232. doi: 10.1002/mus.880080308. [DOI] [PubMed] [Google Scholar]
  18. Tindall R. S., Rollins J. A., Phillips J. T., Greenlee R. G., Wells L., Belendiuk G. Preliminary results of a double-blind, randomized, placebo-controlled trial of cyclosporine in myasthenia gravis. N Engl J Med. 1987 Mar 19;316(12):719–724. doi: 10.1056/NEJM198703193161205. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES