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. 1991 Feb;54(2):116–118. doi: 10.1136/jnnp.54.2.116

Neurofibrillary tangles in dementia pugilistica are ubiquitinated.

G E Dale 1, P N Leigh 1, P Luthert 1, B H Anderton 1, G W Roberts 1
PMCID: PMC1014344  PMID: 1850450

Abstract

Ubiquitin, a protein thought to be involved in the ATP-dependent non-lysosomal degradation of abnormal proteins, has already been identified as a component of neurofibrillary tangles in Alzheimer's disease. We have examined ubiquitin immunoreactivity in a unique collection of brains from 16 ex-boxers including 11 with dementia pugilistica. Neurofibrillary tangles of dementia pugilistica were labelled with an affinity purified antiserum to ubiquitin, and BF10, a monoclonal antibody to a neurofilament epitope.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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