Table 2.

PDZ interactors with the E protein of the most pathogenic coronaviruses.

Coronavirus	SARS-CoV-1	SARS-CoV-2	MERS	Reference
PDZbm	Type 2: DLLV	Type 2: DLLV	Type 3: DEWV
Human PDZ interactors	HTRA1 LNX2 MLLT4 PALS1 PARD3 PDZD2 PTPN13 SDCBP TJP1	HTRA1 LNX2 MAST2 MLLT4 NHERF1 PALS1 PARD3 PTPN13 RADIL SDCBP SNX27 TJP1	APBA1 ARHGAP21 FRMPD4 GIPC2 GORASP1 GORASP2 HTRA1 HTRA3 INADL LAP2 LNX2 LRRC7 MAGI1 MAGI2 PARD3 PDZD2 PTPN13 RGS3 RIMS1 RIMS2 SDCBP SIPA1L2 SNX27 SYNPO2L TJP1 TJP3	[21,51,52,53,54,55]